Neprilysin 4:一种重要的多肽酶，具有多方面的生理相关性。

IF 2.9 4区生物学 Q3 BIOCHEMISTRY & MOLECULAR BIOLOGY

Biological Chemistry Pub Date : 2023-04-25 DOI:10.1515/hsz-2022-0286

Annika Buhr, Ronja Schiemann, Heiko Meyer

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引用次数: 1

摘要

Neprilysins是一种高度保守的外切酶，它能水解并使细胞外空间的信号肽失活。本文以黑腹果蝇(Drosophila melanogaster)的Neprilysin 4为研究对象，对该肽酶的生理相关性进行了综述。特别注意的是在中枢神经系统调节摄食行为和胰岛素样肽表达的neprilysin的作用。此外，我们评估了肽酶在控制肌细胞肌浆和内质网Ca2+ atp酶活性方面的功能，以及详细的潜在分子机制。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Neprilysin 4: an essential peptidase with multifaceted physiological relevance.

Neprilysins are highly conserved ectoenzymes that hydrolyze and thus inactivate signaling peptides in the extracellular space. Herein, we focus on Neprilysin 4 from Drosophila melanogaster and evaluate the existing knowledge on the physiological relevance of the peptidase. Particular attention is paid to the role of the neprilysin in regulating feeding behavior and the expression of insulin-like peptides in the central nervous system. In addition, we assess the function of the peptidase in controlling the activity of the sarcoplasmic and endoplasmic reticulum Ca²⁺ ATPase in myocytes, as well as the underlying molecular mechanism in detail.

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来源期刊

Biological Chemistry 生物-生化与分子生物学

CiteScore

7.20

自引率

0.00%

发文量

审稿时长

4-8 weeks

期刊介绍： Biological Chemistry keeps you up-to-date with all new developments in the molecular life sciences. In addition to original research reports, authoritative reviews written by leading researchers in the field keep you informed about the latest advances in the molecular life sciences. Rapid, yet rigorous reviewing ensures fast access to recent research results of exceptional significance in the biological sciences. Papers are published in a "Just Accepted" format within approx.72 hours of acceptance.