巨噬细胞在骨折愈合中的作用:最近的更新和治疗观点的叙述回顾。

Q1 Biochemistry, Genetics and Molecular Biology
Bianca Braga Frade, Rhayra Braga Dias, Sara Gemini Piperni, Danielle Cabral Bonfim
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引用次数: 6

摘要

目的:本文综述了巨噬细胞在骨折愈合中的作用的最新研究进展,探讨了巨噬细胞与骨巩固失败的关系,并展望了促进骨再生的先进和创新疗法的发展前景。背景:骨折后骨可以完全恢复其形态和功能。然而,骨折愈合的再生过程是复杂的,受多种因素的影响,包括巨噬细胞活性。这些细胞在骨再生的所有阶段都存在于骨折部位,它们的普遍耗竭或介导其分化、极化和/或功能的受体的敲低导致骨折愈合受损。方法:结合关键词“巨噬细胞”、“骨折愈合”、“骨再生”、“骨修复”,在PubMed数据库中进行文献检索。过去几年(2017-2022年)发表的文章报道了体内长骨骨折愈合实验的证据。结论:在过去五年中发表的关于巨噬细胞在骨折愈合中的作用的研究加强了这样一种观点,即成功巩固的关键是M1/M2群体之间的适当平衡,它们在这一过程中具有不同但互补的作用。这些发现为几种巨噬细胞靶向治疗的发展开辟了有希望的新途径,包括调节巨噬细胞分化和极化的分子和/或生物材料的管理,巨噬细胞前体的局部移植,以及使用外泌体传递影响巨噬细胞活动的信号分子。然而,需要更多的研究来更好地了解巨噬细胞表型的多样性及其在骨折愈合每一步中的具体作用,并破译巨噬细胞与其他微环境细胞类型(如内皮细胞和骨骼干细胞/祖细胞)之间体内串扰的关键分子机制。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

The role of macrophages in fracture healing: a narrative review of the recent updates and therapeutic perspectives.

The role of macrophages in fracture healing: a narrative review of the recent updates and therapeutic perspectives.

The role of macrophages in fracture healing: a narrative review of the recent updates and therapeutic perspectives.

The role of macrophages in fracture healing: a narrative review of the recent updates and therapeutic perspectives.

Objective: This review addresses the latest advances in research on the role of macrophages in fracture healing, exploring their relationship with failures in bone consolidation and the perspectives for the development of advanced and innovative therapies to promote bone regeneration.

Background: The bone can fully restore its form and function after a fracture. However, the regenerative process of fracture healing is complex and is influenced by several factors, including macrophage activity. These cells have been found in the fracture site at all stages of bone regeneration, and their general depletion or the knockdown of receptors that mediate their differentiation, polarization, and/or function result in impaired fracture healing.

Methods: The literature search was carried out in the PubMed database, using combinations of the keywords "macrophage", "fracture healing, "bone regeneration", and "bone repair". Articles published within the last years (2017-2022) reporting evidence from in vivo long bone fracture healing experiments were included.

Conclusions: Studies published in the last five years on the role of macrophages in fracture healing strengthened the idea that what appears to be essential when it comes to a successful consolidation is the right balance between the M1/M2 populations, which have different but complementary roles in the process. These findings opened promising new avenues for the development of several macrophage-targeted therapies, including the administration of molecules and/or biomaterials intended to regulate macrophage differentiation and polarization, the local transplantation of macrophage precursors, and the use of exosomes to deliver signaling molecules that influence macrophage activities. However, more research is still warranted to better understand the diversity of macrophage phenotypes and their specific roles in each step of fracture healing and to decipher the key molecular mechanisms involved in the in vivo crosstalk between macrophages and other microenvironmental cell types, such as endothelial and skeletal stem/progenitor cells.

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来源期刊
Stem cell investigation
Stem cell investigation Biochemistry, Genetics and Molecular Biology-Developmental Biology
CiteScore
5.80
自引率
0.00%
发文量
9
期刊介绍: The Stem Cell Investigation (SCI; Stem Cell Investig; Online ISSN: 2313-0792) is a free access, peer-reviewed online journal covering basic, translational, and clinical research on all aspects of stem cells. It publishes original research articles and reviews on embryonic stem cells, induced pluripotent stem cells, adult tissue-specific stem/progenitor cells, cancer stem like cells, stem cell niche, stem cell technology, stem cell based drug discovery, and regenerative medicine. Stem Cell Investigation is indexed in PubMed/PMC since April, 2016.
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