Cailey I Kerley, Tin Q Nguyen, Karthik Ramadass, Laurie E Cutting, Bennett A Landman, Matthew Berger
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引用次数: 0
摘要
目的在电子健康记录(EHR)上实现表观范围关联研究(PheWAS)的交互式可视化:pyPheWAS Explorer 允许用户在一个精简的图形界面上检查组变量、测试假设、设计 PheWAS 模型并评估结果:pyPheWAS Explorer 用于建立一个 PheWAS 模型,将性别和贫困指数作为协变量,Explorer 对该模型的结果可视化显示了已知的多动症合并症。讨论:pyPheWAS Explorer 可用于快速调查潜在的新电子病历关联。结论:pyPheWAS Explorer 为设计、执行和分析 PheWAS 实验提供了无缝的图形界面,强调回归类型和协方差选择的探索性分析。
pyPheWAS Explorer: a visualization tool for exploratory analysis of phenome-disease associations.
Objective: To enable interactive visualization of phenome-wide association studies (PheWAS) on electronic health records (EHR).
Materials and methods: Current PheWAS technologies require familiarity with command-line interfaces and lack end-to-end data visualizations. pyPheWAS Explorer allows users to examine group variables, test assumptions, design PheWAS models, and evaluate results in a streamlined graphical interface.
Results: A cohort of attention deficit hyperactivity disorder (ADHD) subjects and matched non-ADHD controls is examined. pyPheWAS Explorer is used to build a PheWAS model including sex and deprivation index as covariates, and the Explorer's result visualization for this model reveals known ADHD comorbidities.
Discussion: pyPheWAS Explorer may be used to rapidly investigate potentially novel EHR associations. Broader applications include deployment for clinical experts and preliminary exploration tools for institutional EHR repositories.
Conclusion: pyPheWAS Explorer provides a seamless graphical interface for designing, executing, and analyzing PheWAS experiments, emphasizing exploratory analysis of regression types and covariate selection.