小胶质细胞在阿尔茨海默病病理中的作用。

IF 1.8 4区医学 Q3 CLINICAL NEUROLOGY

Current Alzheimer research Pub Date : 2023-01-01 DOI:10.2174/1567205020666230203112351

Gao Rong, Wu Hongrong, Li Qingqi, Zhao Jianfeng

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引用次数: 2

摘要

淀粉样斑块和神经原纤维缠结是阿尔茨海默病(AD)的两个主要特征。小胶质细胞作为大脑常驻吞噬细胞，在Aβ病理和tau病理中具有不同的作用。在这篇综述中，我们讨论了小胶质细胞在Aβ和tau的形成、清除和扩散中的功能。许多与小胶质细胞相关的受体和酶参与阿尔茨海默病的病理，因此被认为是阿尔茨海默病的潜在靶点。因此，利用小胶质细胞有助于限制阿尔茨海默病的病理。综上所述，本文综述了小胶质细胞在阿尔茨海默病病理中的作用及可能的治疗方法。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Roles of Microglia in AD Pathology.

Amyloid plaques and neurofibrillary tangles are two main characteristics of Alzheimer's disease (AD). As cerebral resident phagocytes, microglia have different roles in Aβ pathology and tau pathology. In this review, we discuss microglial functions in the formation, clearance, and spread of Aβ and tau. Many receptors and enzymes, which are related to microglia, participate in AD pathologies and thus are thought to be potential targets of AD. So, making use of microglia can be beneficial to confine AD pathologies. To sum up, this article review the roles of microglia in AD pathology and possible corresponding treatments.

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来源期刊

Current Alzheimer research 医学-神经科学

CiteScore

4.00

自引率

4.80%

发文量

审稿时长

4-8 weeks

期刊介绍： Current Alzheimer Research publishes peer-reviewed frontier review, research, drug clinical trial studies and letter articles on all areas of Alzheimer’s disease. This multidisciplinary journal will help in understanding the neurobiology, genetics, pathogenesis, and treatment strategies of Alzheimer’s disease. The journal publishes objective reviews written by experts and leaders actively engaged in research using cellular, molecular, and animal models. The journal also covers original articles on recent research in fast emerging areas of molecular diagnostics, brain imaging, drug development and discovery, and clinical aspects of Alzheimer’s disease. Manuscripts are encouraged that relate to the synergistic mechanism of Alzheimer''s disease with other dementia and neurodegenerative disorders. Book reviews, meeting reports and letters-to-the-editor are also published. The journal is essential reading for researchers, educators and physicians with interest in age-related dementia and Alzheimer’s disease. Current Alzheimer Research provides a comprehensive ''bird''s-eye view'' of the current state of Alzheimer''s research for neuroscientists, clinicians, health science planners, granting, caregivers and families of this devastating disease.