生物降解长效注射剂：平台技术与工业挑战。

Q1 Pharmacology, Toxicology and Pharmaceutics

Handbook of experimental pharmacology Pub Date : 2024-01-01 DOI:10.1007/164_2023_651

Marieta Duvnjak, Alessia Villois, Farshad Ramazani

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引用次数: 0

摘要

长效注射剂已被用于造福慢性病患者。到目前为止，已经建立了几种可生物降解的长效平台技术，包括药物负载聚合物微颗粒、植入物（预成型和原位成型）、油基溶液和水悬浮液。在本章中，我们总结了所有已上市的技术平台，并讨论了它们在开发过程中面临的挑战，包括但不限于控制药物释放、粒度、稳定性、灭菌、放大生产等。最后，我们将讨论成功开发长效注射剂的重要标准。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Biodegradable Long-Acting Injectables: Platform Technology and Industrial Challenges.

Long-acting injectables have been used to benefit patients with chronic diseases. So far, several biodegradable long-acting platform technologies including drug-loaded polymeric microparticles, implants (preformed and in situ forming), oil-based solutions, and aqueous suspension have been established. In this chapter, we summarize all the marketed technology platforms and discuss their challenges regarding development including but not limited to controlling drug release, particle size, stability, sterilization, scale-up manufacturing, etc. Finally, we discuss important criteria to consider for the successful development of long-acting injectables.

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来源期刊

Handbook of experimental pharmacology Pharmacology, Toxicology and Pharmaceutics-Pharmacology, Toxicology and Pharmaceutics (all)

CiteScore

5.20

自引率

0.00%

发文量

期刊介绍： The Handbook of Experimental Pharmacology is one of the most authoritative and influential book series in pharmacology. It provides critical and comprehensive discussions of the most significant areas of pharmacological research, written by leading international authorities. Each volume in the series represents the most informative and contemporary account of its subject available, making it an unrivalled reference source.