卫生工作者第一次注射辉瑞生物技术疫苗后不良反应的发生率和相关因素。

IF 0.5 4区医学 Q4 SURGERY

Cirugia Y Cirujanos Pub Date : 2023-01-01 DOI:10.24875/CIRU.21000749

José E López-Contreras, Patricia Paredes-Casillas, Jaime Morales-Romero, Francisco E Castillo-Vélez, Juan C Lona-Reyes, Martín Bedolla-Barajas

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引用次数: 0

摘要

目的:了解辉瑞- biontech疫苗首剂后不良反应(AR)的发生率，并探讨与AR相关的因素。方法:采用回顾性队列研究。数据是通过网上回答的流行病学调查获得的。通过多因素分析确定早期(< 2小时)和晚期(≥2小时)急性呼吸道感染的相关因素。结果:共纳入2295名医护人员;其中，累计发生AR的发生率为18.2%(95%可信区间:16.6 ~ 19.8)，其中以晚期发病为主(78.2%)。增加早期AR风险的相关因素是女性(比值比[OR]: 2.23, p = 0.002)和医务人员(比值比:1.56;P = 0.041)。晚期为女性(OR: 1.94;P < 0.0001);另一方面，糖尿病(OR: 0.46;p = 0.021)，哮喘(OR: 0.53;p = 0.040)和吸烟(OR: 0.44, p = 0.002)为负相关因素。有趣的是，COVID-19病史与早期或晚期AR均无关。结论:卫生保健工作者因辉瑞- biontech疫苗而出现某种类型AR的风险< 20%。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Incidencia y factores asociados con las reacciones adversas tras la primera dosis de la vacuna Pfizer-BioNTech en trabajadores de la salud.

Objective: To determine the incidence of adverse reactions (AR) after the first dose of Pfizer-BioNTech vaccine, and to identify some factors associated with AR.

Method: A retrospective cohort study was conducted. Data were obtained through an epidemiological survey answered online. Multivariate analyses were performed to identify factors associated with early (< 2 h) and late (≥ 2 h) AR.

Results: A total of 2295 health care workers were included; in them, the cumulative incidence of AR was 18.2% (95% confidence interval: 16.6-19.8), where the majority were late (78.2%). The associated factors that increased the risk of early AR were being female (odds ratio [OR]: 2.23, p = 0.002) and belonging to the medical staff (OR: 1.56; p = 0.041). In late AR were being female (OR: 1.94; p < 0.0001); on the other hand, diabetes (OR: 0.46; p = 0.021), asthma (OR: 0.53; p = 0.040) and smoking (OR: 0.44, p = 0.002) were inversely associated factors. Interestingly, history of COVID-19 was not associated with either early or late AR.

Conclusions: The risk of presenting some type of AR due to the Pfizer-BioNTech vaccine in health care workers is < 20%.

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来源期刊

Cirugia Y Cirujanos 医学-外科

CiteScore

0.90

自引率

20.00%

发文量

207

审稿时长

6-12 weeks

期刊介绍： Cirugía y Cirujanoses exponente del desarrollo académico, científico, médico, quirúrgico y tecnológico en materia de salud en México y en el ámbito internacional. Es una revista bimestral, open access, revisada por pares, que publica en español y en inglés (traducido sin coste para los autores) artículos científicos originales, casos clínicos, artículos de revisión de interés general y cartas al editor. Los artículos se seleccionan y publican siguiendo un riguroso análisis, de acuerdo con los estándares internacionalmente aceptados. Sus espacios están abiertos a los académicos, así como a todo miembro de la comunidad médica que manifieste interés por utilizar este foro para publicar sus trabajos.