问题的核心:理解和管理α - gal综合征。

IF 6.2 Q1 IMMUNOLOGY
Jessica D Macdougall, Kevin O Thomas, Onyinye I Iweala
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引用次数: 7

摘要

α -半乳糖综合征是一种非常规的食物过敏,其特征是ige介导的对半乳糖- α -1,3-半乳糖(α -半乳糖)的超敏反应,而不是对食物蛋白质的超敏反应。在这篇综述中,我们讨论了α -gal综合征如何重塑我们目前对食物过敏发病机制的概念。α -半乳糖IgE的发展与蜱叮咬有关,尽管其他寄生虫可能促进对α -半乳糖残留物的敏化。我们回顾了参与α -半乳糖综合征致敏期和效应期的免疫细胞群,并描述了目前对摄入α -半乳糖的过敏反应可以延迟几个小时的理解。我们回顾了alpha-gal综合征管理的基础,即避免,但也讨论了抗组胺药、肥大细胞稳定剂的使用,以及补充和替代疗法、生物制品和口服免疫疗法在这种情况管理中的新兴作用。α -半乳糖综合征影响含有或源自哺乳动物产品的药物和医疗器械的安全性和耐受性,影响的生活质量远远超出了食物选择。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

The Meat of the Matter: Understanding and Managing Alpha-Gal Syndrome.

The Meat of the Matter: Understanding and Managing Alpha-Gal Syndrome.

Alpha-gal syndrome is an unconventional food allergy, characterized by IgE-mediated hypersensitivity responses to the glycan galactose-alpha-1,3-galactose (alpha-gal) and not to a food-protein. In this review, we discuss how alpha-gal syndrome reframes our current conception of the mechanisms of pathogenesis of food allergy. The development of alpha-gal IgE is associated with tick bites though the possibility of other parasites promoting sensitization to alpha-gal remains. We review the immune cell populations involved in the sensitization and effector phases of alpha-gal syndrome and describe the current understanding of why allergic responses to ingested alpha-gal can be delayed by several hours. We review the foundation of management in alpha-gal syndrome, namely avoidance, but also discuss the use of antihistamines, mast cell stabilizers, and the emerging role of complementary and alternative therapies, biological products, and oral immunotherapy in the management of this condition. Alpha-gal syndrome influences the safety and tolerability of medications and medical devices containing or derived from mammalian products and impacts quality of life well beyond food choices.

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来源期刊
CiteScore
16.50
自引率
0.00%
发文量
7
审稿时长
16 weeks
期刊介绍: Immuno Targets and Therapy is an international, peer-reviewed open access journal focusing on the immunological basis of diseases, potential targets for immune based therapy and treatment protocols employed to improve patient management. Basic immunology and physiology of the immune system in health, and disease will be also covered.In addition, the journal will focus on the impact of management programs and new therapeutic agents and protocols on patient perspectives such as quality of life, adherence and satisfaction.
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