德国弥漫性大b细胞淋巴瘤患者的医疗资源利用和相关费用:回顾性健康声明数据分析

IF 3.2 Q2 ONCOLOGY

Oncology and Therapy Pub Date : 2023-03-01 Epub Date: 2022-11-29 DOI:10.1007/s40487-022-00211-6

Peter Borchmann, Jan-Michel Heger, Jörg Mahlich, Michael S Papadimitrious, Sybille Riou, Barbara Werner

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引用次数: 1

摘要

弥漫性大b细胞淋巴瘤(DLBCL)是最常见的非霍奇金淋巴瘤，发病率越来越高。尽管与DLBCL相关的疾病负担很高，但关于德国DLBCL患者的医疗资源利用率(HCRU)和相关成本的数据有限。方法:使用德国法定健康保险的670万参保人的大型索赔数据库，我们确定了2011年至2018年(索引日期)期间新诊断为DLBCL的患者。治疗线是根据一组预定义的药物确定的。HCRU和相关费用收集整个后指数期和每条治疗线。结果:共有2495例DLBCL患者符合分析条件。术后平均随访时间为41.7个月。在随访期间，1991名患者开始一线治疗，868名患者开始二线治疗，354名患者开始三线治疗。总体而言，患者在指数后平均每月住院5.24(6.17)天。在抗癌治疗方面，一线治疗增加到9例(10.9例)，二线治疗增加到8.7例(13.7例)，三线治疗增加到9.4例(15.8例)。每个病人每月的总成本(PPPM)从指数之前的421欧元(875.70欧元)增加到指数之后的3695欧元(4652欧元)。在治疗线上，一线的PPPM费用为17,170欧元(10,246欧元)，二线为13,362欧元(12,685欧元)，三线治疗为12,112欧元(16,173欧元)。在一线、二线和三线治疗期间，未经时间调整的绝对成本分别为59,868欧元(43,331欧元)、35,870欧元(37,387欧元)和28,832欧元(40,540欧元)。主要的成本驱动因素是住院费用(占总费用的71%)和药品购置费用(占总费用的18%)。结论:德国DLBCL的经济负担较高，主要是住院费用和药费。因此，迫切需要新的具有成本效益的治疗方案，既能降低疾病负担，又能保持经济上的可行性，以支持越来越多的患有这种侵袭性疾病的患者。

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Healthcare Resource Utilization and Associated Costs of German Patients with Diffuse Large B-Cell Lymphoma: A Retrospective Health Claims Data Analysis.

Introduction: Diffuse large B-cell lymphoma (DLBCL) is the most common form of non-Hodgkin's lymphoma with increasing prevalence. Although the disease burden associated with DLBCL is high, only limited data on healthcare resource utilization (HCRU) and associated costs of German patients with DLBCL is available.

Methods: Using a large claims database of the German statutory health insurance with 6.7 million enrollees, we identified patients who were newly diagnosed with DLBCL between 2011 and 2018 (index date). Treatment lines were identified based on a predefined set of medication. HCRU and related costs were collected for the entire post index period and per treatment line.

Results: A total of 2495 incident DLBCL patients were eligible for the analysis. The average follow-up time after index was 41.7 months. During follow-up, 1991 patients started a first-line treatment, 868 a second-line treatment, and 354 a third-line treatment. Overall, patients spent on average (SD) 5.24 (6.17) days per month in hospital after index. While on anti-cancer treatment, this number increased to nine (10.9) in first-line, 8.7 (13.7) in second-line, and 9.4 (15.8) in third-line treatments. Overall costs per patient per month (PPPM) increased from €421 (875.70) before to €3695 (4652) after index. While on a treatment line, PPPM costs were €17,170 (10,246) in first-line, €13,362 (12,685) in second-line, and €12,112 (16,173) in third-line treatments. Time-unadjusted absolute costs sum up to €59,868 (43,331), €35,870 (37,387), and €28,832 (40,540) during first-line, second-line, and third-line treatments, respectively. The main cost drivers were hospitalizations (71% of total costs) and drug acquisition costs (18% of total costs).

Conclusions: The financial burden of DLBCL in Germany is high, mainly due to hospitalization and drug costs. Therefore, there is a high medical need for new cost-effective therapeutic options that can lower the disease burden and remain financially viable to support the growing number of patients with this aggressive disease.

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来源期刊

Oncology and Therapy ONCOLOGY-

CiteScore

3.40

自引率

0.00%

发文量

审稿时长

6 weeks

期刊介绍： Now indexed in PubMed Aims and Scope Oncology and Therapy is an international, peer reviewed, rapid-publication (peer review in 2 weeks, published 3–4 weeks from acceptance) journal dedicated to the publication of high-quality pre-clinical, clinical (all phases), observational, real-world, and health outcomes research around the discovery, development, and use of therapeutics and interventions (including devices) across all therapeutic areas. Studies relating to diagnostics and diagnosis, pharmacoeconomics, public health, epidemiology, quality of life, and patient care, management, and education are also encouraged. The journal is of interest to a broad audience of healthcare professionals and publishes original research, reviews, communications and letters. The journal is read by a global audience and receives submissions from all over the world. Oncology and Therapy will consider all scientifically sound research be it positive, confirmatory or negative data. Submissions are welcomed whether they relate to an international and/or a country-specific audience, something that is crucially important when researchers are trying to target more specific patient populations. This inclusive approach allows the journal to assist in the dissemination of all scientifically and ethically sound research. Rapid Publication The journal’s rapid publication timelines aim for a peer review decision within 2 weeks of submission. If an article is accepted it will be published online 3-4 weeks from acceptance. These rapid timelines are achieved through the combination of a dedicated in-house editorial team, who closely manage article workflow, and an extensive Editorial and Advisory Board who assist with rapid peer review. This allows the journal to support the rapid dissemination of research, whilst still providing robust peer review. 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For further information about digital features, please contact the journal editor (see ‘Contact the Journal’ for email address), and see the ‘Guidelines for digital features and plain language summaries’ document under ‘Submission guidelines’. Preprints We encourage posting of preprints of primary research manuscripts on preprint servers, authors'' or institutional websites, and open communications between researchers whether on community preprint servers or preprint commenting platforms. Posting of preprints is not considered prior publication and will not jeopardize consideration in our journals. Please see here for further information on preprint sharing: https://www.springer.com/gp/authors-editors/journal-author/journal-author-helpdesk/submission/1302#c16721550 Peer Review Process Upon submission, manuscripts are assessed by the editorial team to ensure they fit within the aims and scope of the journal and are also checked for plagiarism. 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