鼻咽癌的上颈部照射与标准全颈部照射:一项系统回顾和荟萃分析。

IF 2 4区医学 Q3 ONCOLOGY

Tumori Pub Date : 2023-12-01 Epub Date: 2023-02-16 DOI:10.1177/03008916231154765

Francesca De Felice, Claudia Marchetti, Maria Serpone, AnnaMaria Camarda, Barbara Vischioni, Rossana Ingargiola, Daniela Musio, Ester Orlandi

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引用次数: 1

摘要

目的:评价上颈部放射治疗与标准全颈部放射治疗在鼻咽癌患者中的作用。方法:我们进行了基于PRISMA指南的系统评价和荟萃分析。随机临床试验评估了非转移性N0-1型鼻咽癌患者的上颈部放疗与全颈部放疗合并或不合并化疗的疗效。这些研究在PubMed、Embase和Cochrane图书馆检索到2022年3月。评估生存结果，包括总生存期、无远处转移生存期和无复发生存期以及毒化率。结果:最终纳入两项随机临床试验，共纳入样本747例。与全颈部照射相比，上颈部照射具有相似的总生存率(风险比= 0.69,95%可信区间= 0.37-1.30)、远端无转移生存率(风险比= 0.92,95%可信区间= 0.53-1.60)和无复发生存率(风险比= 1.03,95%可信区间= 0.69-1.55)。上颈部照射与全颈部照射在急性和晚期毒性方面均无差异。结论:该荟萃分析支持上颈部照射在这类患者中的潜在作用。需要进一步的研究来证实结果。

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Upper-neck irradiation versus standard whole-neck irradiation in nasopharyngeal carcinoma: A systematic review and meta-analysis.

Purpose: To evaluate the role of upper-neck irradiation versus standard whole-neck irradiation in patients with N0-1 nasopharyngeal carcinoma.

Methods: We conducted a PRISMA guideline based systematic review and meta-analysis. Randomized clinical trials assessing upper-neck irradiation versus whole-neck irradiation with or without chemotherapy in non-metastatic N0-1 nasopharyngeal carcinoma patients were identified. The studies were searched on the PubMed, Embase and Cochrane library up to March 2022. Survival outcomes, including overall survival, distant metastasis-free survival and relapse-free survival, and toxicities rate were evaluated.

Results: There were two randomized clinical trials with 747 samples finally included. Upper-neck irradiation had similar overall survival (hazard ratio = 0.69, 95% confidence interval = 0.37-1.30), distant metastasis-free survival (hazard ratio = 0.92, 95% confidence interval = 0.53-1.60) and relapse-free survival (risk ratio = 1.03, 95% confidence interval = 0.69-1.55) compared to whole-neck irradiation. No differences in both acute and late toxicities were recorded between upper-neck irradiation and whole-neck irradiation.

Conclusion: This meta-analysis supports the potential role of upper-neck irradiation in this population of patients. Further research is needed to confirm results.

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来源期刊

Tumori 医学-肿瘤学

CiteScore

3.50

自引率

0.00%

发文量

审稿时长

6 months

期刊介绍： Tumori Journal covers all aspects of cancer science and clinical practice with a strong focus on prevention, translational medicine and clinically relevant reports. We invite the publication of randomized trials and reports on large, consecutive patient series that investigate the real impact of new techniques, drugs and devices inday-to-day clinical practice.