Tarik Sengoz, Yeliz Arman Karakaya, Aziz Gültekin, Sevda Yilmaz, Ergun Erdem, Burcu Yapar Taskoylu, Zehra Kesen, Olga Yaylali, Dogangun Yuksel
{"title":"F-18 FDG PET/CT在预测浸润性导管性乳腺癌新辅助化疗反应中的作用","authors":"Tarik Sengoz, Yeliz Arman Karakaya, Aziz Gültekin, Sevda Yilmaz, Ergun Erdem, Burcu Yapar Taskoylu, Zehra Kesen, Olga Yaylali, Dogangun Yuksel","doi":"10.4274/ejbh.galenos.2023.2023-1-3","DOIUrl":null,"url":null,"abstract":"<p><strong>Objective: </strong>The role of baseline and post-treatment standardized uptake value (SUV<sub>max</sub>) values in predicting pathological response in patients with breast cancer after neoadjuvant chemotherapy (NAC).</p><p><strong>Materials and methods: </strong>Thirty patients with invasive ductal breast cancer were included in this retrospective study. F-18 fluorodeoxyglucose (FDG) positron emission tomography/computerized tomography (PET/CT) examinations were performed before and after NAC. Pretreatment SUV<sub>max</sub> (SUV<sub>max</sub> I), post-treatment SUV<sub>max</sub> (SUV<sub>max</sub> II) and ΔSUV<sub>max</sub> values of primary breast cancer were obtained. Breast tumor pathology preparations were examined for the evaluation of tumor response according to the Miller and Payne classification. Patients were grouped as responding to treatment (pCR) and unresponsive to treatment (nonpCR). In all analyses, p<0.05 was considered statistically significant.</p><p><strong>Results: </strong>The mean age of the 30 patients included in the study was 51.2±11.98 years. In the study-defined grouping, 13 patients (43.3%) were nonresponders and 17 patients (56.7%) were responders. ΔSUV<sub>max</sub> was significantly greater in the responders group compared to the nonresponders group, while SUV<sub>max</sub> II was lower (<i>p</i> = 0.001 and <i>p</i> = 0.004, respectively). There was no significant difference between the responders and nonresponders in terms of age, tumor diameter, and SUV<sub>max</sub> I values. Multivariate logistic regression analysis showed ΔSUV<sub>max</sub> to be the only independent predictive factor for pCR.</p><p><strong>Conclusion: </strong>F-18 FDG PET/CT was an effective method in evaluating the treatment response after NAC in breast cancer, and ΔSUV<sub>max</sub> and post-treatment SUV<sub>max</sub> can be used to predict the response of the primary tumor to treatment.</p>","PeriodicalId":11885,"journal":{"name":"European journal of breast health","volume":null,"pages":null},"PeriodicalIF":0.0000,"publicationDate":"2023-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10071889/pdf/ejbh-19-159.pdf","citationCount":"1","resultStr":"{\"title\":\"Role of F-18 FDG PET/CT in Predicting Response to Neoadjuvant Chemotherapy in Invasive Ductal Breast Cancer.\",\"authors\":\"Tarik Sengoz, Yeliz Arman Karakaya, Aziz Gültekin, Sevda Yilmaz, Ergun Erdem, Burcu Yapar Taskoylu, Zehra Kesen, Olga Yaylali, Dogangun Yuksel\",\"doi\":\"10.4274/ejbh.galenos.2023.2023-1-3\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Objective: </strong>The role of baseline and post-treatment standardized uptake value (SUV<sub>max</sub>) values in predicting pathological response in patients with breast cancer after neoadjuvant chemotherapy (NAC).</p><p><strong>Materials and methods: </strong>Thirty patients with invasive ductal breast cancer were included in this retrospective study. F-18 fluorodeoxyglucose (FDG) positron emission tomography/computerized tomography (PET/CT) examinations were performed before and after NAC. Pretreatment SUV<sub>max</sub> (SUV<sub>max</sub> I), post-treatment SUV<sub>max</sub> (SUV<sub>max</sub> II) and ΔSUV<sub>max</sub> values of primary breast cancer were obtained. Breast tumor pathology preparations were examined for the evaluation of tumor response according to the Miller and Payne classification. Patients were grouped as responding to treatment (pCR) and unresponsive to treatment (nonpCR). In all analyses, p<0.05 was considered statistically significant.</p><p><strong>Results: </strong>The mean age of the 30 patients included in the study was 51.2±11.98 years. In the study-defined grouping, 13 patients (43.3%) were nonresponders and 17 patients (56.7%) were responders. ΔSUV<sub>max</sub> was significantly greater in the responders group compared to the nonresponders group, while SUV<sub>max</sub> II was lower (<i>p</i> = 0.001 and <i>p</i> = 0.004, respectively). There was no significant difference between the responders and nonresponders in terms of age, tumor diameter, and SUV<sub>max</sub> I values. Multivariate logistic regression analysis showed ΔSUV<sub>max</sub> to be the only independent predictive factor for pCR.</p><p><strong>Conclusion: </strong>F-18 FDG PET/CT was an effective method in evaluating the treatment response after NAC in breast cancer, and ΔSUV<sub>max</sub> and post-treatment SUV<sub>max</sub> can be used to predict the response of the primary tumor to treatment.</p>\",\"PeriodicalId\":11885,\"journal\":{\"name\":\"European journal of breast health\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2023-04-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10071889/pdf/ejbh-19-159.pdf\",\"citationCount\":\"1\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"European journal of breast health\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.4274/ejbh.galenos.2023.2023-1-3\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"European journal of breast health","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.4274/ejbh.galenos.2023.2023-1-3","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
Role of F-18 FDG PET/CT in Predicting Response to Neoadjuvant Chemotherapy in Invasive Ductal Breast Cancer.
Objective: The role of baseline and post-treatment standardized uptake value (SUVmax) values in predicting pathological response in patients with breast cancer after neoadjuvant chemotherapy (NAC).
Materials and methods: Thirty patients with invasive ductal breast cancer were included in this retrospective study. F-18 fluorodeoxyglucose (FDG) positron emission tomography/computerized tomography (PET/CT) examinations were performed before and after NAC. Pretreatment SUVmax (SUVmax I), post-treatment SUVmax (SUVmax II) and ΔSUVmax values of primary breast cancer were obtained. Breast tumor pathology preparations were examined for the evaluation of tumor response according to the Miller and Payne classification. Patients were grouped as responding to treatment (pCR) and unresponsive to treatment (nonpCR). In all analyses, p<0.05 was considered statistically significant.
Results: The mean age of the 30 patients included in the study was 51.2±11.98 years. In the study-defined grouping, 13 patients (43.3%) were nonresponders and 17 patients (56.7%) were responders. ΔSUVmax was significantly greater in the responders group compared to the nonresponders group, while SUVmax II was lower (p = 0.001 and p = 0.004, respectively). There was no significant difference between the responders and nonresponders in terms of age, tumor diameter, and SUVmax I values. Multivariate logistic regression analysis showed ΔSUVmax to be the only independent predictive factor for pCR.
Conclusion: F-18 FDG PET/CT was an effective method in evaluating the treatment response after NAC in breast cancer, and ΔSUVmax and post-treatment SUVmax can be used to predict the response of the primary tumor to treatment.
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