左旋酒石酸抑制地米那嗪诱导的孤立大鼠主动脉血管舒张作用

Q2 Medicine

Cardiovascular and Hematological Agents in Medicinal Chemistry Pub Date : 2023-01-01 DOI:10.2174/1871525721666230406075646

Ayoub Amssayef, Ismail Bouadid, Mohamed Eddouks

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引用次数: 0

摘要

目的：该研究探讨了L-酒石酸对地米那嗪诱导的血管舒张作用的影响：背景：已知地米那秦可通过刺激血管紧张素转换酶（ACE-2）诱导血管舒张：本研究旨在采用体外方法研究L-酒石酸对地米那嗪诱导的血管舒张作用的影响：在本次研究中，研究了L-酒石酸对地米那嗪诱导的血管舒张的抑制作用：结果：结果证实，L-酒石酸能够以剂量依赖的方式抑制地米那嗪诱导的血管舒张：结论：这项研究为酒石酸抑制地西泮诱导的血管舒张提供了重要的实验证据。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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L-Tartaric Acid Inhibits Diminazene-induced Vasorelaxation in Isolated Rat Aorta.

Aims: The study investigated the effect of L-tartaric acid on diminazene-indiuced vasorelaxation.

Background: Diminazene is known to induce vasorelaxation through the stimulation of angiotensin- converting enzyme (ACE-2).

Objective: This work was designed to study the effect of L-tartaric acid on diminazene-induced vasorelaxation using an ex vivo approach.

Materials and methods: In the current investigation, the inhibitory effect of L-tartaric acid on diminazene-induced relaxation.

Results: The results confirmed that L-tartaric acid was able to inhibit in a dose-dependent manner diminazene-induced vasorelaxation.

Conclusion: This investigation provides important experimental evidence of the efficacy of Ltartaric acid in inhibiting diminazene-induced vasorelaxation.

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来源期刊

Cardiovascular and Hematological Agents in Medicinal Chemistry Medicine-Cardiology and Cardiovascular Medicine

CiteScore

2.70

自引率

0.00%

发文量

期刊介绍： Cardiovascular & Hematological Agents in Medicinal Chemistry aims to cover all the latest and outstanding developments in medicinal chemistry and rational drug design for the discovery of new Cardiovascular & Hematological Agents. Each issue contains a series of timely in-depth reviews written by leaders in the field covering a range of current topics in Cardiovascular & Hematological medicinal chemistry. Cardiovascular & Hematological Agents in Medicinal Chemistry is an essential journal for every medicinal chemist who wishes to be kept informed and up-to-date with the latest and most important developments in cardiovascular & hematological drug discovery.