Emma S Chambers, Milica Vukmanovic-Stejic, Carolin T Turner, Barbara B Shih, Hugh Trahair, Gabriele Pollara, Evdokia Tsaliki, Malcolm Rustin, Tom C Freeman, Neil A Mabbott, Mahdad Noursadeghi, Adrian R Martineau, Arne N Akbar
{"title":"补充维生素 D3 可增强老年人的抗原特异性免疫力。","authors":"Emma S Chambers, Milica Vukmanovic-Stejic, Carolin T Turner, Barbara B Shih, Hugh Trahair, Gabriele Pollara, Evdokia Tsaliki, Malcolm Rustin, Tom C Freeman, Neil A Mabbott, Mahdad Noursadeghi, Adrian R Martineau, Arne N Akbar","doi":"10.1093/immadv/ltaa008","DOIUrl":null,"url":null,"abstract":"<p><strong>Introduction: </strong>Ageing is associated with increased number of infections, decreased vaccine efficacy and increased systemic inflammation termed inflammageing. These changes are reflected by reduced recall responses to varicella zoster virus (VZV) challenge in the skin of older adults. Vitamin D deficiency is more common in the old and has been associated with frailty and increased inflammation. In addition, vitamin D increases immunoregulatory mechanisms and therefore has the potential to inhibit inflammageing.</p><p><strong>Objectives: </strong>We investigated the use of vitamin D<sub>3</sub> replacement to enhance cutaneous antigen-specific immunity in older adults (≥65 years).</p><p><strong>Methods: </strong>Vitamin D insufficient older adults (<i>n</i> = 18) were administered 6400IU of vitamin D<sub>3</sub>/day orally for 14 weeks. Antigen-specific immunity to VZV was assessed by clinical score assessment of the injection site and transcriptional analysis of skin biopsies collected from challenged injection sites pre- and post-vitamin D<sub>3</sub> replacement.</p><p><strong>Results: </strong>We showed that older adults had reduced VZV-specific cutaneous immune response and increased non-specific inflammation as compared to young. Increased non-specific inflammation observed in the skin of older adults negatively correlated with vitamin D sufficiency. We showed that vitamin D<sub>3</sub> supplementation significantly increased the response to cutaneous VZV antigen challenge in older adults. This enhancement was associated with a reduction in inflammatory monocyte infiltration with a concomitant enhancement of T cell recruitment to the site of antigen challenge in the skin.</p><p><strong>Conclusion: </strong>Vitamin D<sub>3</sub> replacement can boost antigen-specific immunity in older adults with sub-optimal vitamin D status.</p>","PeriodicalId":73353,"journal":{"name":"Immunotherapy advances","volume":null,"pages":null},"PeriodicalIF":4.1000,"publicationDate":"2020-11-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9585673/pdf/","citationCount":"0","resultStr":"{\"title\":\"Vitamin D<sub>3</sub> replacement enhances antigen-specific immunity in older adults.\",\"authors\":\"Emma S Chambers, Milica Vukmanovic-Stejic, Carolin T Turner, Barbara B Shih, Hugh Trahair, Gabriele Pollara, Evdokia Tsaliki, Malcolm Rustin, Tom C Freeman, Neil A Mabbott, Mahdad Noursadeghi, Adrian R Martineau, Arne N Akbar\",\"doi\":\"10.1093/immadv/ltaa008\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Introduction: </strong>Ageing is associated with increased number of infections, decreased vaccine efficacy and increased systemic inflammation termed inflammageing. These changes are reflected by reduced recall responses to varicella zoster virus (VZV) challenge in the skin of older adults. Vitamin D deficiency is more common in the old and has been associated with frailty and increased inflammation. In addition, vitamin D increases immunoregulatory mechanisms and therefore has the potential to inhibit inflammageing.</p><p><strong>Objectives: </strong>We investigated the use of vitamin D<sub>3</sub> replacement to enhance cutaneous antigen-specific immunity in older adults (≥65 years).</p><p><strong>Methods: </strong>Vitamin D insufficient older adults (<i>n</i> = 18) were administered 6400IU of vitamin D<sub>3</sub>/day orally for 14 weeks. Antigen-specific immunity to VZV was assessed by clinical score assessment of the injection site and transcriptional analysis of skin biopsies collected from challenged injection sites pre- and post-vitamin D<sub>3</sub> replacement.</p><p><strong>Results: </strong>We showed that older adults had reduced VZV-specific cutaneous immune response and increased non-specific inflammation as compared to young. Increased non-specific inflammation observed in the skin of older adults negatively correlated with vitamin D sufficiency. We showed that vitamin D<sub>3</sub> supplementation significantly increased the response to cutaneous VZV antigen challenge in older adults. This enhancement was associated with a reduction in inflammatory monocyte infiltration with a concomitant enhancement of T cell recruitment to the site of antigen challenge in the skin.</p><p><strong>Conclusion: </strong>Vitamin D<sub>3</sub> replacement can boost antigen-specific immunity in older adults with sub-optimal vitamin D status.</p>\",\"PeriodicalId\":73353,\"journal\":{\"name\":\"Immunotherapy advances\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":4.1000,\"publicationDate\":\"2020-11-25\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9585673/pdf/\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Immunotherapy advances\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.1093/immadv/ltaa008\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"2021/1/1 0:00:00\",\"PubModel\":\"eCollection\",\"JCR\":\"Q2\",\"JCRName\":\"IMMUNOLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Immunotherapy advances","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1093/immadv/ltaa008","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2021/1/1 0:00:00","PubModel":"eCollection","JCR":"Q2","JCRName":"IMMUNOLOGY","Score":null,"Total":0}
引用次数: 0
摘要
导言:老龄化与感染次数增加、疫苗效力下降和全身炎症增加(称为炎症老化)有关。这些变化反映在老年人皮肤对水痘带状疱疹病毒(VZV)挑战的回忆反应降低。维生素 D 缺乏症在老年人中更为常见,并与体弱和炎症加重有关。此外,维生素 D 还能增强免疫调节机制,因此具有抑制炎症的潜力:我们研究了使用维生素 D3 替代品增强老年人(≥65 岁)皮肤抗原特异性免疫力的方法:维生素 D 不足的老年人(n = 18)每天口服 6400IU 的维生素 D3,持续 14 周。通过对注射部位进行临床评分评估,以及对维生素 D3 补充前后从受质疑注射部位采集的皮肤活检组织进行转录分析,评估对 VZV 的抗原特异性免疫力:结果:我们发现,与年轻人相比,老年人的 VZV 特异性皮肤免疫反应降低,非特异性炎症增加。在老年人皮肤中观察到的非特异性炎症增加与维生素 D 的充足性呈负相关。我们的研究表明,补充维生素 D3 能显著提高老年人对皮肤 VZV 抗原挑战的反应。这种增强与炎性单核细胞浸润的减少有关,与此同时,皮肤抗原挑战部位的 T 细胞招募也得到了增强:结论:维生素 D3 替代品可增强维生素 D 状态不达标的老年人的抗原特异性免疫力。
Vitamin D3 replacement enhances antigen-specific immunity in older adults.
Introduction: Ageing is associated with increased number of infections, decreased vaccine efficacy and increased systemic inflammation termed inflammageing. These changes are reflected by reduced recall responses to varicella zoster virus (VZV) challenge in the skin of older adults. Vitamin D deficiency is more common in the old and has been associated with frailty and increased inflammation. In addition, vitamin D increases immunoregulatory mechanisms and therefore has the potential to inhibit inflammageing.
Objectives: We investigated the use of vitamin D3 replacement to enhance cutaneous antigen-specific immunity in older adults (≥65 years).
Methods: Vitamin D insufficient older adults (n = 18) were administered 6400IU of vitamin D3/day orally for 14 weeks. Antigen-specific immunity to VZV was assessed by clinical score assessment of the injection site and transcriptional analysis of skin biopsies collected from challenged injection sites pre- and post-vitamin D3 replacement.
Results: We showed that older adults had reduced VZV-specific cutaneous immune response and increased non-specific inflammation as compared to young. Increased non-specific inflammation observed in the skin of older adults negatively correlated with vitamin D sufficiency. We showed that vitamin D3 supplementation significantly increased the response to cutaneous VZV antigen challenge in older adults. This enhancement was associated with a reduction in inflammatory monocyte infiltration with a concomitant enhancement of T cell recruitment to the site of antigen challenge in the skin.
Conclusion: Vitamin D3 replacement can boost antigen-specific immunity in older adults with sub-optimal vitamin D status.