Emel Zergani, Amir Rashidi, Jalal Rostamzadeh, Mohammad Razmkabir, Jens Tetens
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To investigate the effect of c.963A <math><mi>></mi></math> G on litter size, we utilized four different genetic models assuming dominant (<i>GG</i> <math><mo>+</mo></math> <i>GA</i> vs. <i>AA</i>), recessive (<i>GG</i> vs. <i>GA</i> <math><mo>+</mo></math> <i>AA</i>), additive (<i>GG</i> vs. <i>AA</i>) and co-dominant (<i>GG</i> <math><mo>+</mo></math> <i>AA</i> vs. <i>GA</i>) model of inheritance. Data were analyzed under random-effects models based on the <math> <mrow><msup><mi>I</mi> <mn>2</mn></msup> </mrow> </math> value. Furthermore, sensitivity analysis was carried out to validate the stability of results. The results showed that the c.963A <math><mi>></mi></math> G polymorphism is associated with litter size when applying a dominant model (standardized mean difference (SMD) is 0.815, 95 % CI [0.170, 1.461], <math><mi>P</mi></math> value <math><mo>=</mo></math> 0.013) and also with an additive model (SMD <math><mo>=</mo></math> 0.755, 95 % CI [0.111, 1.400], <math><mi>P</mi></math> value <math><mo>=</mo></math> 0.022). However, the effect of c.963A <math><mi>></mi></math> G polymorphism was not significant under recessive (SMD <math><mo>=</mo></math> 0.186, 95 % CI [ <math><mo>-</mo></math> 0.195, 4.259], <math><mi>P</mi></math> value <math><mo>=</mo></math> 0.339) and co-dominant (SMD <math><mo>=</mo></math> <math><mo>-</mo></math> 0.119, 95 % CI [ <math><mo>-</mo></math> 0.525, 0.288], <math><mi>P</mi></math> value <math><mo>=</mo></math> 0.568) models. Sensitivity analysis demonstrated that dropping studies with wide confidence intervals affects overall results under the assumption of an additive model. The meta-analysis results revealed that the <i>AA</i> genotype could be positively connected with litter size in goats.</p>","PeriodicalId":55481,"journal":{"name":"Archiv Fur Tierzucht-Archives of Animal Breeding","volume":"65 3","pages":"309-318"},"PeriodicalIF":1.6000,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9901516/pdf/","citationCount":"1","resultStr":"{\"title\":\"Meta-analysis of association between c.963A<i>></i>G single-nucleotide polymorphism on <i>BMP15</i> gene and litter size in goats.\",\"authors\":\"Emel Zergani, Amir Rashidi, Jalal Rostamzadeh, Mohammad Razmkabir, Jens Tetens\",\"doi\":\"10.5194/aab-65-309-2022\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><p>Litter size is an important economic trait in the goat industry. Previous studies on the bone morphogenetic protein 15 (<i>BMP15</i>) gene detected some single-nucleotide polymorphisms (SNPs) such as c.963A <math><mi>></mi></math> G that were associated with an increase in ovulation rate and litter size. The aim of this study was to conduct a meta-analysis on the effect of this polymorphism on litter size. We gathered and pooled data from five eligible published studies. To investigate the effect of c.963A <math><mi>></mi></math> G on litter size, we utilized four different genetic models assuming dominant (<i>GG</i> <math><mo>+</mo></math> <i>GA</i> vs. <i>AA</i>), recessive (<i>GG</i> vs. <i>GA</i> <math><mo>+</mo></math> <i>AA</i>), additive (<i>GG</i> vs. <i>AA</i>) and co-dominant (<i>GG</i> <math><mo>+</mo></math> <i>AA</i> vs. <i>GA</i>) model of inheritance. Data were analyzed under random-effects models based on the <math> <mrow><msup><mi>I</mi> <mn>2</mn></msup> </mrow> </math> value. Furthermore, sensitivity analysis was carried out to validate the stability of results. The results showed that the c.963A <math><mi>></mi></math> G polymorphism is associated with litter size when applying a dominant model (standardized mean difference (SMD) is 0.815, 95 % CI [0.170, 1.461], <math><mi>P</mi></math> value <math><mo>=</mo></math> 0.013) and also with an additive model (SMD <math><mo>=</mo></math> 0.755, 95 % CI [0.111, 1.400], <math><mi>P</mi></math> value <math><mo>=</mo></math> 0.022). However, the effect of c.963A <math><mi>></mi></math> G polymorphism was not significant under recessive (SMD <math><mo>=</mo></math> 0.186, 95 % CI [ <math><mo>-</mo></math> 0.195, 4.259], <math><mi>P</mi></math> value <math><mo>=</mo></math> 0.339) and co-dominant (SMD <math><mo>=</mo></math> <math><mo>-</mo></math> 0.119, 95 % CI [ <math><mo>-</mo></math> 0.525, 0.288], <math><mi>P</mi></math> value <math><mo>=</mo></math> 0.568) models. Sensitivity analysis demonstrated that dropping studies with wide confidence intervals affects overall results under the assumption of an additive model. The meta-analysis results revealed that the <i>AA</i> genotype could be positively connected with litter size in goats.</p>\",\"PeriodicalId\":55481,\"journal\":{\"name\":\"Archiv Fur Tierzucht-Archives of Animal Breeding\",\"volume\":\"65 3\",\"pages\":\"309-318\"},\"PeriodicalIF\":1.6000,\"publicationDate\":\"2022-01-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9901516/pdf/\",\"citationCount\":\"1\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Archiv Fur Tierzucht-Archives of Animal Breeding\",\"FirstCategoryId\":\"97\",\"ListUrlMain\":\"https://doi.org/10.5194/aab-65-309-2022\",\"RegionNum\":3,\"RegionCategory\":\"农林科学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q2\",\"JCRName\":\"AGRICULTURE, DAIRY & ANIMAL SCIENCE\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Archiv Fur Tierzucht-Archives of Animal Breeding","FirstCategoryId":"97","ListUrlMain":"https://doi.org/10.5194/aab-65-309-2022","RegionNum":3,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"AGRICULTURE, DAIRY & ANIMAL SCIENCE","Score":null,"Total":0}
引用次数: 1
摘要
产仔数是山羊产业的一个重要经济指标。先前对骨形态发生蛋白15 (bone morphogenetic protein 15, BMP15)基因的研究发现了一些单核苷酸多态性(snp)，如c.963A > G，这些多态性与排卵率和产仔数的增加有关。本研究的目的是对这种多态性对窝产仔数的影响进行荟萃分析。我们收集并汇总了5项符合条件的已发表研究的数据。为了研究c.963A > G对产仔数的影响，采用显性遗传(GG + GA vs. AA)、隐性遗传(GG vs. GA + AA)、加性遗传(GG vs. AA)和共显性遗传(GG + AA vs. GA) 4种遗传模型。采用基于i2值的随机效应模型对数据进行分析。进一步进行敏感性分析，验证结果的稳定性。结果表明，采用显性模型(标准化平均差值(SMD)为0.815,95 % CI [0.170, 1.461]， P值 = 0.013)和加性模型(SMD = 0.755,95 % CI [0.111, 1.400]， P值 = 0.022)，c.963A > G多态性与凋落物数相关。然而,c.963A的影响> G多态性隐性下不显著(SMD = 0.186,95 % CI (- 0.195, 4.259), P值 = 0.339)和共显性(SMD = - 0.119,95 % CI (- 0.525, 0.288), P值 = 0.568)模型。敏感性分析表明，在加性模型的假设下，具有宽置信区间的放弃研究影响总体结果。meta分析结果显示，AA基因型与山羊产仔数呈正相关。
Meta-analysis of association between c.963A>G single-nucleotide polymorphism on BMP15 gene and litter size in goats.
Litter size is an important economic trait in the goat industry. Previous studies on the bone morphogenetic protein 15 (BMP15) gene detected some single-nucleotide polymorphisms (SNPs) such as c.963A G that were associated with an increase in ovulation rate and litter size. The aim of this study was to conduct a meta-analysis on the effect of this polymorphism on litter size. We gathered and pooled data from five eligible published studies. To investigate the effect of c.963A G on litter size, we utilized four different genetic models assuming dominant (GGGA vs. AA), recessive (GG vs. GAAA), additive (GG vs. AA) and co-dominant (GGAA vs. GA) model of inheritance. Data were analyzed under random-effects models based on the value. Furthermore, sensitivity analysis was carried out to validate the stability of results. The results showed that the c.963A G polymorphism is associated with litter size when applying a dominant model (standardized mean difference (SMD) is 0.815, 95 % CI [0.170, 1.461], value 0.013) and also with an additive model (SMD 0.755, 95 % CI [0.111, 1.400], value 0.022). However, the effect of c.963A G polymorphism was not significant under recessive (SMD 0.186, 95 % CI [ 0.195, 4.259], value 0.339) and co-dominant (SMD 0.119, 95 % CI [ 0.525, 0.288], value 0.568) models. Sensitivity analysis demonstrated that dropping studies with wide confidence intervals affects overall results under the assumption of an additive model. The meta-analysis results revealed that the AA genotype could be positively connected with litter size in goats.
期刊介绍：
Archives Animal Breeding is an open-access journal publishing original research papers, short communications, brief reports, and reviews by international researchers on scientific progress in farm-animal biology. The journal includes publications in quantitative and molecular genetics, genetic diversity, animal husbandry and welfare, physiology, and reproduction of livestock. It addresses researchers, teachers, stakeholders of academic and educational institutions, as well as industrial and governmental organizations in the field of animal production.
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