四唑融合咪唑吡啶衍生物抗癌剂的合成及生物学评价

IF 2.218 Q2 Chemistry

Chemical Data Collections Pub Date : 2023-10-03 DOI:10.1016/j.cdc.2023.101092

Narendhar Reddy Vanam, Jaya Shree Anireddy

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引用次数: 0

摘要

合成了一系列新的四唑融合咪唑吡啶衍生物(12a-j)，并对其对三种人类癌细胞(MCF7, A549, MDA MB-231)的细胞毒活性进行了评价。所有化合物均经1H NMR、13CNMR和质谱分析证实。其中化合物12b、12c、12d、12h、12i和12j的活性均高于阳性对照阿霉素。

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Synthesis and biological evaluation of tetrazole fused imidazopyridine derivatives as anticancer agents

A new series of tetrazole fused imidazopyridine derivatives (12a-j) were synthesized and evaluated for their cytotoxic activity against three human cancer cell lines (MCF7, A549, MDA MB-231). All these synthesized compounds were confirmed by ¹H NMR, ¹³CNMR and mass spectral analysis. Among them, compounds 12b, 12c, 12d, 12h, 12i and 12j showed more potent activity than the positive control doxorubicin.

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来源期刊

Chemical Data Collections Chemistry-Chemistry (all)

CiteScore

6.10

自引率

0.00%

发文量

169

审稿时长

24 days

期刊介绍： Chemical Data Collections (CDC) provides a publication outlet for the increasing need to make research material and data easy to share and re-use. Publication of research data with CDC will allow scientists to: -Make their data easy to find and access -Benefit from the fast publication process -Contribute to proper data citation and attribution -Publish their intermediate and null/negative results -Receive recognition for the work that does not fit traditional article format. The research data will be published as ''data articles'' that support fast and easy submission and quick peer-review processes. Data articles introduced by CDC are short self-contained publications about research materials and data. They must provide the scientific context of the described work and contain the following elements: a title, list of authors (plus affiliations), abstract, keywords, graphical abstract, metadata table, main text and at least three references. The journal welcomes submissions focusing on (but not limited to) the following categories of research output: spectral data, syntheses, crystallographic data, computational simulations, molecular dynamics and models, physicochemical data, etc.