四唑融合咪唑吡啶衍生物抗癌剂的合成及生物学评价

IF 2.218 Q2 Chemistry

Chemical Data Collections Pub Date : 2023-10-03 DOI:10.1016/j.cdc.2023.101092

Narendhar Reddy Vanam, Jaya Shree Anireddy

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引用次数: 0

摘要

合成了一系列新的四唑融合咪唑吡啶衍生物(12a-j)，并对其对三种人类癌细胞(MCF7, A549, MDA MB-231)的细胞毒活性进行了评价。所有化合物均经1H NMR、13CNMR和质谱分析证实。其中化合物12b、12c、12d、12h、12i和12j的活性均高于阳性对照阿霉素。

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Synthesis and biological evaluation of tetrazole fused imidazopyridine derivatives as anticancer agents

A new series of tetrazole fused imidazopyridine derivatives (12a-j) were synthesized and evaluated for their cytotoxic activity against three human cancer cell lines (MCF7, A549, MDA MB-231). All these synthesized compounds were confirmed by ¹H NMR, ¹³CNMR and mass spectral analysis. Among them, compounds 12b, 12c, 12d, 12h, 12i and 12j showed more potent activity than the positive control doxorubicin.

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来源期刊

Chemical Data Collections Chemistry-Chemistry (all)

CiteScore

6.10

自引率

0.00%

发文量

169

审稿时长

24 days

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