Elías Cuesta-Llavona , Guillermo M. Albaiceta , Marta García-Clemente , Israel D. Duarte-Herrera , Laura Amado-Rodríguez , Tamara Hermida-Valverde , Ana I. Enríquez-Rodriguez , Cristina Hernández-González , Santiago Melón , Marta E. Alvarez-Argüelles , José A. Boga , Susana Rojo-Alba , Daniel Vázquez-Coto , Juan Gómez , Eliecer Coto PhD
{"title":"干扰素诱导的跨膜蛋白3基因(IFITM3) rs34481144 / rs12252单倍型与COVID-19的关系","authors":"Elías Cuesta-Llavona , Guillermo M. Albaiceta , Marta García-Clemente , Israel D. Duarte-Herrera , Laura Amado-Rodríguez , Tamara Hermida-Valverde , Ana I. Enríquez-Rodriguez , Cristina Hernández-González , Santiago Melón , Marta E. Alvarez-Argüelles , José A. Boga , Susana Rojo-Alba , Daniel Vázquez-Coto , Juan Gómez , Eliecer Coto PhD","doi":"10.1016/j.crviro.2021.100016","DOIUrl":null,"url":null,"abstract":"<div><p>The interferon induced transmembrane-protein 3 (IFITM3) plays an important role in the defence against viral infection. <em>IFITM3</em> gene variants have been linked to differences in expression and associated with the risk of severe influenza by some authors. More recently, these variants have been associated with the risk of COVID-19 after SARS-CoV-2 infection. We determined the effect of two common <em>IFITM3</em> polymorphisms (rs34481144 C/T and rs12252 A/G) on the risk of hospitalization due to COVID-19 by comparing 484 patients (152 required support in thr intensive care unit, ICU) and 182 age and sex matched controls (no disease symptoms). We found significantly higher frequencies of rs34481144 T and rs12252 G carriers among the patients (OR = 2.02 and OR = 1.51, respectively). None of the two variants were associated with ICU-admission or death. We found a significantly higher frequency of rs34481144 CC + rs12252 AA genotype carriers among the controls, suggesting a protective effect (<strong>p</strong> = <strong>0.001, OR</strong> = <strong>0.56, 95%CI</strong> = <strong>0.40</strong>–<strong>0.80).</strong> Moreover, haplotype rs34481144 C - rs12252 A was significantly increased in the controls (p = 0.008, OR = 0.71, 95%CI = 0.55–0.91).</p><p>Our results showed a significant effect of the <em>IFITM3</em> variants in the risk for hospitalization after SARS-CoV-2 infection.</p></div>","PeriodicalId":72755,"journal":{"name":"Current research in virological science","volume":"2 ","pages":"Article 100016"},"PeriodicalIF":0.0000,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2666478X21000106/pdfft?md5=39328f73561396e183881376e34456df&pid=1-s2.0-S2666478X21000106-main.pdf","citationCount":"18","resultStr":"{\"title\":\"Association between the interferon-induced transmembrane protein 3 gene (IFITM3) rs34481144 / rs12252 haplotypes and COVID-19\",\"authors\":\"Elías Cuesta-Llavona , Guillermo M. Albaiceta , Marta García-Clemente , Israel D. Duarte-Herrera , Laura Amado-Rodríguez , Tamara Hermida-Valverde , Ana I. Enríquez-Rodriguez , Cristina Hernández-González , Santiago Melón , Marta E. Alvarez-Argüelles , José A. Boga , Susana Rojo-Alba , Daniel Vázquez-Coto , Juan Gómez , Eliecer Coto PhD\",\"doi\":\"10.1016/j.crviro.2021.100016\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><p>The interferon induced transmembrane-protein 3 (IFITM3) plays an important role in the defence against viral infection. <em>IFITM3</em> gene variants have been linked to differences in expression and associated with the risk of severe influenza by some authors. More recently, these variants have been associated with the risk of COVID-19 after SARS-CoV-2 infection. We determined the effect of two common <em>IFITM3</em> polymorphisms (rs34481144 C/T and rs12252 A/G) on the risk of hospitalization due to COVID-19 by comparing 484 patients (152 required support in thr intensive care unit, ICU) and 182 age and sex matched controls (no disease symptoms). We found significantly higher frequencies of rs34481144 T and rs12252 G carriers among the patients (OR = 2.02 and OR = 1.51, respectively). None of the two variants were associated with ICU-admission or death. We found a significantly higher frequency of rs34481144 CC + rs12252 AA genotype carriers among the controls, suggesting a protective effect (<strong>p</strong> = <strong>0.001, OR</strong> = <strong>0.56, 95%CI</strong> = <strong>0.40</strong>–<strong>0.80).</strong> Moreover, haplotype rs34481144 C - rs12252 A was significantly increased in the controls (p = 0.008, OR = 0.71, 95%CI = 0.55–0.91).</p><p>Our results showed a significant effect of the <em>IFITM3</em> variants in the risk for hospitalization after SARS-CoV-2 infection.</p></div>\",\"PeriodicalId\":72755,\"journal\":{\"name\":\"Current research in virological science\",\"volume\":\"2 \",\"pages\":\"Article 100016\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2021-01-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://www.sciencedirect.com/science/article/pii/S2666478X21000106/pdfft?md5=39328f73561396e183881376e34456df&pid=1-s2.0-S2666478X21000106-main.pdf\",\"citationCount\":\"18\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Current research in virological science\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S2666478X21000106\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Current research in virological science","FirstCategoryId":"1085","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S2666478X21000106","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
Association between the interferon-induced transmembrane protein 3 gene (IFITM3) rs34481144 / rs12252 haplotypes and COVID-19
The interferon induced transmembrane-protein 3 (IFITM3) plays an important role in the defence against viral infection. IFITM3 gene variants have been linked to differences in expression and associated with the risk of severe influenza by some authors. More recently, these variants have been associated with the risk of COVID-19 after SARS-CoV-2 infection. We determined the effect of two common IFITM3 polymorphisms (rs34481144 C/T and rs12252 A/G) on the risk of hospitalization due to COVID-19 by comparing 484 patients (152 required support in thr intensive care unit, ICU) and 182 age and sex matched controls (no disease symptoms). We found significantly higher frequencies of rs34481144 T and rs12252 G carriers among the patients (OR = 2.02 and OR = 1.51, respectively). None of the two variants were associated with ICU-admission or death. We found a significantly higher frequency of rs34481144 CC + rs12252 AA genotype carriers among the controls, suggesting a protective effect (p = 0.001, OR = 0.56, 95%CI = 0.40–0.80). Moreover, haplotype rs34481144 C - rs12252 A was significantly increased in the controls (p = 0.008, OR = 0.71, 95%CI = 0.55–0.91).
Our results showed a significant effect of the IFITM3 variants in the risk for hospitalization after SARS-CoV-2 infection.
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