Kosmas I Paraskevas, Dimitri P Mikhailidis, Francesco Spinelli, Gianluca Faggioli, Luca Saba, Mauro Silvestrini, Alexei Svetlikov, Francesco Stilo, Rodolfo Pini, Piotr Myrcha, Vincenzo DI Lazzaro, Pier L Antignani, Pavel Poredos, Gaetano Lanza
{"title":"无症状颈动脉狭窄和认知障碍。","authors":"Kosmas I Paraskevas, Dimitri P Mikhailidis, Francesco Spinelli, Gianluca Faggioli, Luca Saba, Mauro Silvestrini, Alexei Svetlikov, Francesco Stilo, Rodolfo Pini, Piotr Myrcha, Vincenzo DI Lazzaro, Pier L Antignani, Pavel Poredos, Gaetano Lanza","doi":"10.23736/S0021-9509.23.12620-6","DOIUrl":null,"url":null,"abstract":"<p><strong>Introduction: </strong>The aim of this review was to assess the evidence supporting an association between asymptomatic carotid stenosis (ACS) with impaired cognitive function due to chronic cerebral hypoperfusion and/or silent cerebral embolization.</p><p><strong>Evidence acquisition: </strong>PubMed/Medline, Embase and the Cochrane databases were searched up to December 1, 2022 to identify studies focusing on the association between ACS and cognitive function, as well as the mechanisms involved.</p><p><strong>Evidence synthesis: </strong>A total of 49 studies were identified. The evidence supports an association between ACS and progressive cognitive deterioration. The mechanisms involved in the cognitive decline associated with ACS include cerebral hypoperfusion and silent cerebral embolization. Irrespective of the mechanism involved, severe ACS is associated with a progressive decline in several aspects of cognitive function, including global cognition, memory and executive function.</p><p><strong>Conclusions: </strong>Patients with ACS are at increased risk of developing a progressive decline in their cognitive function. The evidence from the present systematic review suggests that it may be inappropriate to consider ACS patients developing cognitive dysfunction as \"asymptomatic\". Besides stroke, myocardial infarction and death rates, future studies should include evaluation of cognitive function as part of their outcomes.</p>","PeriodicalId":50245,"journal":{"name":"Journal of Cardiovascular Surgery","volume":null,"pages":null},"PeriodicalIF":1.4000,"publicationDate":"2023-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"4","resultStr":"{\"title\":\"Asymptomatic carotid stenosis and cognitive impairment.\",\"authors\":\"Kosmas I Paraskevas, Dimitri P Mikhailidis, Francesco Spinelli, Gianluca Faggioli, Luca Saba, Mauro Silvestrini, Alexei Svetlikov, Francesco Stilo, Rodolfo Pini, Piotr Myrcha, Vincenzo DI Lazzaro, Pier L Antignani, Pavel Poredos, Gaetano Lanza\",\"doi\":\"10.23736/S0021-9509.23.12620-6\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Introduction: </strong>The aim of this review was to assess the evidence supporting an association between asymptomatic carotid stenosis (ACS) with impaired cognitive function due to chronic cerebral hypoperfusion and/or silent cerebral embolization.</p><p><strong>Evidence acquisition: </strong>PubMed/Medline, Embase and the Cochrane databases were searched up to December 1, 2022 to identify studies focusing on the association between ACS and cognitive function, as well as the mechanisms involved.</p><p><strong>Evidence synthesis: </strong>A total of 49 studies were identified. The evidence supports an association between ACS and progressive cognitive deterioration. The mechanisms involved in the cognitive decline associated with ACS include cerebral hypoperfusion and silent cerebral embolization. Irrespective of the mechanism involved, severe ACS is associated with a progressive decline in several aspects of cognitive function, including global cognition, memory and executive function.</p><p><strong>Conclusions: </strong>Patients with ACS are at increased risk of developing a progressive decline in their cognitive function. The evidence from the present systematic review suggests that it may be inappropriate to consider ACS patients developing cognitive dysfunction as \\\"asymptomatic\\\". Besides stroke, myocardial infarction and death rates, future studies should include evaluation of cognitive function as part of their outcomes.</p>\",\"PeriodicalId\":50245,\"journal\":{\"name\":\"Journal of Cardiovascular Surgery\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":1.4000,\"publicationDate\":\"2023-04-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"4\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Journal of Cardiovascular Surgery\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.23736/S0021-9509.23.12620-6\",\"RegionNum\":4,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q3\",\"JCRName\":\"CARDIAC & CARDIOVASCULAR SYSTEMS\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of Cardiovascular Surgery","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.23736/S0021-9509.23.12620-6","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"CARDIAC & CARDIOVASCULAR SYSTEMS","Score":null,"Total":0}
Asymptomatic carotid stenosis and cognitive impairment.
Introduction: The aim of this review was to assess the evidence supporting an association between asymptomatic carotid stenosis (ACS) with impaired cognitive function due to chronic cerebral hypoperfusion and/or silent cerebral embolization.
Evidence acquisition: PubMed/Medline, Embase and the Cochrane databases were searched up to December 1, 2022 to identify studies focusing on the association between ACS and cognitive function, as well as the mechanisms involved.
Evidence synthesis: A total of 49 studies were identified. The evidence supports an association between ACS and progressive cognitive deterioration. The mechanisms involved in the cognitive decline associated with ACS include cerebral hypoperfusion and silent cerebral embolization. Irrespective of the mechanism involved, severe ACS is associated with a progressive decline in several aspects of cognitive function, including global cognition, memory and executive function.
Conclusions: Patients with ACS are at increased risk of developing a progressive decline in their cognitive function. The evidence from the present systematic review suggests that it may be inappropriate to consider ACS patients developing cognitive dysfunction as "asymptomatic". Besides stroke, myocardial infarction and death rates, future studies should include evaluation of cognitive function as part of their outcomes.
期刊介绍：
The Journal of Cardiovascular Surgery publishes scientific papers on cardiac, thoracic and vascular surgery. Manuscripts may be submitted in the form of editorials, original articles, review articles, case reports, therapeutical notes, special articles and letters to the Editor.
Manuscripts are expected to comply with the instructions to authors which conform to the Uniform Requirements for Manuscripts Submitted to Biomedical Editors by the International Committee of Medical Journal Editors (www.icmje.org). Articles not conforming to international standards will not be considered for acceptance.
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