精神分裂症的海马功能障碍和啮齿动物模型精神病的海马突触可塑性异常:选择性回顾。

IF 3.6 3区医学 Q2 PHARMACOLOGY & PHARMACY

Pharmacopsychiatry Pub Date : 2023-03-01 DOI:10.1055/a-0960-9846

Julia C Bartsch, Björn H Schott, Joachim Behr

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引用次数: 6

摘要

精神分裂症是一种复杂的异质性精神疾病，影响着全球约1%的人口。海马体功能障碍与精神分裂症的认知缺陷和阳性症状有关。在这里，我们从临床角度简要回顾了目前关于海马加工中断的研究结果，然后重点介绍了利用精神病n -甲基- d -天冬氨酸受体功能障碍模型和遗传模型的相关发现对海马突触异常可塑性的临床前研究。综上所述，这些研究结果表明，适应不良的海马突触可塑性及其外在连接是精神分裂症患者认知障碍的机制基础。

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Hippocampal Dysfunction in Schizophrenia and Aberrant Hippocampal Synaptic Plasticity in Rodent Model Psychosis: a Selective Review.

Schizophrenia is a complex, heterogeneous psychiatric disorder that affects about 1% of the global population. Hippocampal dysfunction has been linked to both cognitive deficits and positive symptoms in schizophrenia. Here, we briefly review current findings on disrupted hippocampal processing from a clinical perspective before concentrating on preclinical studies of aberrant hippocampal synaptic plasticity using the N-methyl-D-aspartate receptor hypofunction model of psychosis and related findings from genetic models. Taken together, the results put the case for maladaptive hippocampal synaptic plasticity and its extrinsic connections as mechanistic underpinnings of cognitive impairments in schizophrenia.

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来源期刊

Pharmacopsychiatry 医学-精神病学

CiteScore

7.10

自引率

9.30%

发文量

审稿时长

6-12 weeks

期刊介绍： Covering advances in the fi eld of psychotropic drugs, Pharmaco psychiatry provides psychiatrists, neuroscientists and clinicians with key clinical insights and describes new avenues of research and treatment. The pharmacological and neurobiological bases of psychiatric disorders are discussed by presenting clinical and experimental research.