Claire Lo, Abin Abraham, Cosmin A Bejan, Seth A Reasoner, Mario Davidson, Loren Lipworth, David M Aronoff
{"title":"避孕暴露与育龄妇女尿路感染风险相关:一项病例对照研究。","authors":"Claire Lo, Abin Abraham, Cosmin A Bejan, Seth A Reasoner, Mario Davidson, Loren Lipworth, David M Aronoff","doi":"10.1080/13625187.2022.2156278","DOIUrl":null,"url":null,"abstract":"<p><strong>Purpose: </strong>Although non-barrier contraception is commonly prescribed, the risk of urinary tract infections (UTI) with contraceptive exposure is unclear.</p><p><strong>Materials and methods: </strong>Using data from Vanderbilt University Medical Centre's deidentified electronic health record (EHR), women ages 18-52 were randomly sampled and matched based on age and length of EHR. This case-control analysis tested for association between contraception exposure and outcome using UTI-positive (UTI+) as cases and upper respiratory infection+ (URI+) as controls.</p><p><strong>Results: </strong>24,563 UTI + cases (mean EHR: 64.2 months; mean age: 31.2 years) and 48,649 UTI-/URI + controls (mean EHR: 63.2 months; mean age: 31.9 years) were analysed. In the primary analysis, UTI risk was statistically significantly increased for the oral contraceptive pill (OCP; OR = 1.10 [95%CI = 1.02-1.11], <i>p</i> ≤ 0.05), intrauterine device (IUD; OR = 1.13 [95%CI = 1.04-1.23], <i>p</i> ≤ 0.05), etonogestrel implant (Nexplanon<sup>®</sup>; OR = 1.56 [95% CI = 1.24-1.96], <i>p</i> ≤ 0.05), and medroxyprogesterone acetate injectable (Depo-Provera<sup>®</sup>; OR = 2.16 [95%CI = 1.99-2.33], <i>p</i> ≤ 0.05) use compared to women not prescribed contraception. A secondary analysis that included <i>any</i> non-IUD contraception, which could serve as a proxy for sexual activity, demonstrated a small attenuation for the association between UTI and IUD (OR = 1.09 [95%CI = 0.98-1.21], <i>p</i> = 0.13).</p><p><strong>Conclusion: </strong>This study notes potential for a small increase in UTIs with contraceptive use. Prospective studies are required before this information is applied in clinical settings.</p><p><strong>Condensation: </strong>Although non-barrier contraception is commonly prescribed, the risk of urinary tract infections (UTI) with contraceptive exposure is poorly understood. This large-cohort, case-control study notes potential for a small increase in UTIs with contraceptive use.</p>","PeriodicalId":1,"journal":{"name":"Accounts of Chemical Research","volume":null,"pages":null},"PeriodicalIF":16.4000,"publicationDate":"2023-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"1","resultStr":"{\"title\":\"Contraceptive exposure associates with urinary tract infection risk in a cohort of reproductive-age women: a case control study.\",\"authors\":\"Claire Lo, Abin Abraham, Cosmin A Bejan, Seth A Reasoner, Mario Davidson, Loren Lipworth, David M Aronoff\",\"doi\":\"10.1080/13625187.2022.2156278\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Purpose: </strong>Although non-barrier contraception is commonly prescribed, the risk of urinary tract infections (UTI) with contraceptive exposure is unclear.</p><p><strong>Materials and methods: </strong>Using data from Vanderbilt University Medical Centre's deidentified electronic health record (EHR), women ages 18-52 were randomly sampled and matched based on age and length of EHR. This case-control analysis tested for association between contraception exposure and outcome using UTI-positive (UTI+) as cases and upper respiratory infection+ (URI+) as controls.</p><p><strong>Results: </strong>24,563 UTI + cases (mean EHR: 64.2 months; mean age: 31.2 years) and 48,649 UTI-/URI + controls (mean EHR: 63.2 months; mean age: 31.9 years) were analysed. In the primary analysis, UTI risk was statistically significantly increased for the oral contraceptive pill (OCP; OR = 1.10 [95%CI = 1.02-1.11], <i>p</i> ≤ 0.05), intrauterine device (IUD; OR = 1.13 [95%CI = 1.04-1.23], <i>p</i> ≤ 0.05), etonogestrel implant (Nexplanon<sup>®</sup>; OR = 1.56 [95% CI = 1.24-1.96], <i>p</i> ≤ 0.05), and medroxyprogesterone acetate injectable (Depo-Provera<sup>®</sup>; OR = 2.16 [95%CI = 1.99-2.33], <i>p</i> ≤ 0.05) use compared to women not prescribed contraception. A secondary analysis that included <i>any</i> non-IUD contraception, which could serve as a proxy for sexual activity, demonstrated a small attenuation for the association between UTI and IUD (OR = 1.09 [95%CI = 0.98-1.21], <i>p</i> = 0.13).</p><p><strong>Conclusion: </strong>This study notes potential for a small increase in UTIs with contraceptive use. Prospective studies are required before this information is applied in clinical settings.</p><p><strong>Condensation: </strong>Although non-barrier contraception is commonly prescribed, the risk of urinary tract infections (UTI) with contraceptive exposure is poorly understood. 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Contraceptive exposure associates with urinary tract infection risk in a cohort of reproductive-age women: a case control study.
Purpose: Although non-barrier contraception is commonly prescribed, the risk of urinary tract infections (UTI) with contraceptive exposure is unclear.
Materials and methods: Using data from Vanderbilt University Medical Centre's deidentified electronic health record (EHR), women ages 18-52 were randomly sampled and matched based on age and length of EHR. This case-control analysis tested for association between contraception exposure and outcome using UTI-positive (UTI+) as cases and upper respiratory infection+ (URI+) as controls.
Results: 24,563 UTI + cases (mean EHR: 64.2 months; mean age: 31.2 years) and 48,649 UTI-/URI + controls (mean EHR: 63.2 months; mean age: 31.9 years) were analysed. In the primary analysis, UTI risk was statistically significantly increased for the oral contraceptive pill (OCP; OR = 1.10 [95%CI = 1.02-1.11], p ≤ 0.05), intrauterine device (IUD; OR = 1.13 [95%CI = 1.04-1.23], p ≤ 0.05), etonogestrel implant (Nexplanon®; OR = 1.56 [95% CI = 1.24-1.96], p ≤ 0.05), and medroxyprogesterone acetate injectable (Depo-Provera®; OR = 2.16 [95%CI = 1.99-2.33], p ≤ 0.05) use compared to women not prescribed contraception. A secondary analysis that included any non-IUD contraception, which could serve as a proxy for sexual activity, demonstrated a small attenuation for the association between UTI and IUD (OR = 1.09 [95%CI = 0.98-1.21], p = 0.13).
Conclusion: This study notes potential for a small increase in UTIs with contraceptive use. Prospective studies are required before this information is applied in clinical settings.
Condensation: Although non-barrier contraception is commonly prescribed, the risk of urinary tract infections (UTI) with contraceptive exposure is poorly understood. This large-cohort, case-control study notes potential for a small increase in UTIs with contraceptive use.
期刊介绍：
Accounts of Chemical Research presents short, concise and critical articles offering easy-to-read overviews of basic research and applications in all areas of chemistry and biochemistry. These short reviews focus on research from the author’s own laboratory and are designed to teach the reader about a research project. In addition, Accounts of Chemical Research publishes commentaries that give an informed opinion on a current research problem. Special Issues online are devoted to a single topic of unusual activity and significance.
Accounts of Chemical Research replaces the traditional article abstract with an article "Conspectus." These entries synopsize the research affording the reader a closer look at the content and significance of an article. Through this provision of a more detailed description of the article contents, the Conspectus enhances the article's discoverability by search engines and the exposure for the research.
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