[新冠肺炎大流行期间肝移植研究现状]。

Y Zhao, T Chen, J J Zhang
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引用次数: 0

摘要

由严重急性呼吸系统综合征(SARS-CoV-2)引起的冠状病毒病(Covid-19)大流行,极大地改变了我们的日常生活和临床实践。由于大流行期间肝移植的减少和SARS-CoV-2感染引起的肝损伤,等待肝移植候选人的预后更差。由于肝受者长期接受免疫抑制治疗,其感染风险高于一般人群。尽管一些研究表明免疫抑制疗法似乎对感染患者有保护作用,但它也会导致慢性感染。出于对病毒传播风险的担忧,专家共识不建议使用有Covid-19病史的供体肝脏。目前,发表的文章并不支持病毒可以通过捐赠者的肝脏传播给接受者的观点。因此,利用SARS-CoV-2感染供体肝脏进行肝移植的可行性仍存在争议。本文就新冠肺炎大流行期间肝移植研究进展进行综述,为今后肝移植研究提供新的思路。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
[Current research in liver transplantation during the Covid-19 pandemic].

The coronavirus disease (Covid-19) pandemic caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has drastically changed our daily life and clinical practice.Due to the reduction of liver transplantation and the liver injury caused by SARS-CoV-2 infection during the pandemic,the prognosis of waitinglisted liver transplant candidates is worse.Due to the long-term immunosuppressive therapy of liver recipients,their risk of infection is higher than the general population.Although some studies suggested that immunosuppressive therapy seems to have a protective effect in infected patients,it also leads to chronic infection.Due to the concerns about the risk of virus transmission,expert consensus does not recommend the utilization of donor livers with the history of Covid-19.Currently,published articles do not support the argument that virus can be transmitted to recipients through donor livers.Therefore,the feasibility of liver transplantation utilizing donor livers with SARS-CoV-2 infection remains controversial.In this article,current advances in liver transplantation during the Covid-19 pandemic are reviewed to provide a new perspective for liver transplantation in the future.

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