冈比亚 COVID-19 大流行期间呼吸道病毒的传播。

Gates Open Research Pub Date : 2023-03-27 eCollection Date: 2022-01-01 DOI:10.12688/gatesopenres.14155.3
Sheikh Jarju, Elina Senghore, Helen Brotherton, Lucy Affleck, Alasana Saidykhan, Samba Jallow, Ebrima Krubally, Edrisa Sinjanka, Morris Ngor Ndene, Fabakary Bajo, Musa M Sanyang, Binta Saidy, Alasana Bah, Nuredin I Mohammed, Karen Forrest, Ed Clarke, Umberto Dalessandro, Abdul K Sesay, Effua Usuf, Carla Cerami, Anna Roca, Beate Kampmann, Thushan I de Silva
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引用次数: 0

摘要

背景:在许多国家,限制严重急性呼吸系统综合症冠状病毒 2(SARS-CoV-2)传播的非药物干预措施导致其他呼吸道病毒显著减少。然而,非洲的类似数据却很有限。我们探讨了 COVID-19 大流行期间冈比亚流感和鼻病毒等病毒与 SARS-CoV-2 共同传播的程度。 研究方法2020 年 4 月至 2022 年 3 月期间,使用 RT-PCR 技术从 1397 名流感样病例的鼻咽拭子中检测呼吸道病毒。检测 SARS-CoV-2 的方法和病毒多重 RT-PCR 方法如前所述,用于检测甲型和乙型流感、甲型和乙型呼吸道合胞病毒(RSV)、副流感病毒 1-4、人类偏肺病毒(HMPV)、腺病毒、季节性冠状病毒(229E、OC43、NL63)和人类鼻病毒。结果显示总体病毒阳性率为 44.2%,50 岁儿童(39.9%)、50 岁以下儿童(24.3%)、50 岁以上儿童(6.3%)、50 岁以下儿童(6.3%)和 50 岁以上儿童(6.3%)的发病率较高:我们的数据表明,在冈比亚 COVID-19 大流行期间,许多呼吸道病毒继续流行,其中包括人类鼻病毒,尽管在大流行的早期阶段出现了非典型肺炎,并且在预期月份出现了流感高峰。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Circulation of respiratory viruses during the COVID-19 pandemic in The Gambia.

Background: In many countries, non-pharmaceutical interventions to limit severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) transmission resulted in significant reductions in other respiratory viruses. However, similar data from Africa are limited. We explored the extent to which viruses such as influenza and rhinovirus co-circulated with SARS-CoV-2 in The Gambia during the COVID-19 pandemic.  Methods: Between April 2020 and March 2022, respiratory viruses were detected using RT-PCR in nasopharyngeal swabs from 1397 participants with influenza-like illness. An assay to detect SARS-CoV-2 and a viral multiplex RT-PCR assay was used as previously described  to detect influenza A and B, respiratory syncytial virus (RSV) A and B, parainfluenza viruses 1-4, human metapneumovirus (HMPV), adenovirus, seasonal coronaviruses (229E, OC43, NL63) and human rhinovirus. Results: Overall virus positivity was 44.2%, with prevalence higher in children <5 years (80%) compared to children aged 5-17 years (53.1%), adults aged 18-50 (39.5%) and >50 years (39.9%), p<0.0001. After SARS-CoV-2 (18.3%), rhinoviruses (10.5%) and influenza viruses (5.5%) were the most prevalent. SARS-CoV-2 positivity was lower in children <5 (4.3%) and 5-17 years (12.7%) than in adults aged 18-50 (19.3%) and >50 years (24.3%), p<0.0001. In contrast, rhinoviruses were most prevalent in children <5 years (28.7%), followed by children aged 5-17 (15.8%), adults aged 18-50 (8.3%) and >50 years (6.3%), p<0.0001. Four SARS-CoV-2 waves occurred, with 36.1%-52.4% SARS-CoV-2 positivity during peak months. Influenza infections were observed in both 2020 and 2021 during the rainy season as expected (peak positivity 16.4%-23.5%). Peaks of rhinovirus were asynchronous to the months when SARS-CoV-2 and influenza peaked. Conclusion: Our data show that many respiratory viruses continued to circulate during the COVID-19 pandemic in The Gambia, including human rhinoviruses, despite the presence of NPIs during the early stages of the pandemic, and influenza peaks during expected months.

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来源期刊
Gates Open Research
Gates Open Research Immunology and Microbiology-Immunology and Microbiology (miscellaneous)
CiteScore
3.60
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