胶体输注液免疫原性的简单试验-引流淋巴结激活

Lidka Korčáková , E. Paluska , Věra Hašková , J. Kopeček
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引用次数: 10

摘要

小鼠淋巴结内具有核仁合成RNA的淋巴细胞数量增加,并排出输注液注射部位,作为其免疫原性的标志。“活跃”淋巴细胞的百分比在给予基于牛血清或人血红蛋白的制剂3天后显着增加,当检测抗体形成时发现免疫原性。在用Physiogel、Dextran和Duxon处理的小鼠中没有引起这种反应,这些小鼠不会产生任何抗体。所描述的试验可以作为输注溶液和其他物质的免疫原性的快速和经济的测定。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
A Simple Test for Immunogenicity of Colloidal Infusion Solutions - the Draining Lymph Node Activation

The increasing number of lymphocytes with nucleoli synthesizing RNA in the mouse lymph nodes, draining the site of injection of infusion solutions, was used as a marker for their immunogenicity. The percentage of «active» lymphocytes significantly increased 3 days after the administration of preparations based on bovine serum or human haemoglobin which were found immunogenic when testing for antibody formation. Such a reaction was not elicited in mice treated with Physiogel, Dextran and Duxon which do not cause any production of antibodies. The described test may serve as a rapid and economical assay for the immunogenicity of infusion solutions and other substances.

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