Nobumasa Kato, Kanhaiya R. Shah, Henry G. Friesen, Viktor Havlicek
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Effect of chronic treatment with haloperidol on serum prolactin, striatal opiate receptors and β-endorphin content in rat brain and pituitary
1.
1. Rats were treated for 21 days with haloperidol (2mg/kg/day) and prolactin levels were measured serially. The increase in prolactin was obvious throughout the treatment and was even more prominent after repeated injections.
2.
2. Immunoreactive β-endorphin levels were increased in the pituitary, whereas decreased in N. accumbens in rats chronically treated with haloperidol. The opiate receptor binding in the striatum showed no change in treated rats as compared with controls.
3.
3. The present study suggests that 1) tolerance does not develop in prolactin-increasing action of haloperidol; 2) dopamine receptors have a role in the control of immunoreactive β-endorphin in some brain areas; 3) the various dopaminergic pathways in the brain respond differently to chronic treatment with haloperidol in terms of immunoreactive β-endorphin regulation.
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