支持深度局部热疗与放化疗联合治疗膀胱癌的新证据

IF 2.6 3区 医学 Q3 ONCOLOGY
Oliver J. Ott , Udo S. Gaipl , Allison Lamrani , Rainer Fietkau
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引用次数: 1

摘要

几十年来,热疗单独或与放疗和/或化疗联合使用的抗肿瘤潜力一直是各种肿瘤实体临床前和临床研究的主题。总结了附加热疗联合膀胱内注射Mitomycin C治疗浅表非肌肉浸润性膀胱癌症的有益效果以及在外束放疗或放化疗治疗更晚期肿瘤时应用的深层区域微波热疗技术的临床证据。在一些系列中,深部区域热疗结合最初的经尿道电切术和基于顺铂的化疗放疗,可将5年总生存率提高20%。所提供的数据证明,在膀胱保存的多模式治疗的新的渐进前瞻性试验中,轻度局部热疗的新机会是合理的。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
The Emerging Evidence Supporting Integration of Deep Regional Hyperthermia With Chemoradiation in Bladder Cancer

For decades, the antineoplastic potential of hyperthermia alone or in combination with radiotherapy and/or chemotherapy has been subject of intensive preclinical and clinical research in various tumor entities. The clinical evidence on the beneficial effects of additional hyperthermia in combination with intravesical Mitomycin C for superficial non-muscle-invasive bladder cancer as well as for deep regional microwave hyperthermia techniques applied during an external beam radiotherapy or chemoradiation treatment for more advanced tumors are summarized. In some series, deep regional hyperthermia in combination with an initial transurethral resection and Cisplatin-based chemoradiation increased the 5-year overall survival rates up to 20%. The presented data justifies a fresh irrespective chance for mild regional hyperthermia in the context of new progressive prospective trials on multimodality treatment for bladder preservation.

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来源期刊
CiteScore
5.80
自引率
0.00%
发文量
48
审稿时长
>12 weeks
期刊介绍: Each issue of Seminars in Radiation Oncology is compiled by a guest editor to address a specific topic in the specialty, presenting definitive information on areas of rapid change and development. A significant number of articles report new scientific information. Topics covered include tumor biology, diagnosis, medical and surgical management of the patient, and new technologies.
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