心房射血力和脑利钠肽作为脓毒症死亡率的标志物

IF 0.3 Q4 CRITICAL CARE MEDICINE
Mohammed Badr Salim , Hesham Elaasr , Mervat El Damarawy , Ashraf Wadee , Alaa Ashour , Fatma Mohammad Nasr
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引用次数: 1

摘要

背景在脓毒性休克早期,心肌功能受损在预后中起着重要作用。AEF和血浆BNP水平可能是脓毒症患者有价值的预后因素。目的探讨心房射血力(AEF) b型利钠肽(BNP)对脓毒症、严重脓毒症及脓毒症休克预后的预测价值。方法选取40例脓毒症、严重脓毒症和脓毒症患者作为研究对象。患者于入院第1天和第3天行经胸超声心动图检查和BNP测量。回顾性地将患者分为幸存者和非幸存者。结果两组患者BNP水平差异有统计学意义(P = 0.0001)。从第1天到第3天,非生存组BNP升高(p = 0.002),从第1天到第3天,存活组BNP下降(p = 0.001),具有统计学意义。关于回声结果,幸存者和非幸存者在第3天的回声结果差异有统计学意义(P = 0.0001)。ROC曲线显示,第1天、第3天BNP是预测脓毒症患者死亡率的良好指标。结论与BNP水平不同,入院第一天心房射血力不能作为脓毒症患者死亡率的独立预测指标。BNP水平与脓毒症严重程度相关。根据我们的研究,第三天的AEF可能是脓毒症患者生存的一个很好的预测指标。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Atrial ejection force and brain natriuretic peptide as markers for mortality in sepsis

Background

In early stages of septic shock, impaired myocardial function plays an important prognostic role. AEF and Plasma BNP level may be a valuable prognostic factor for patients with sepsis.

Objective

We aimed also to evaluate the value of atrial ejection force (AEF) B-type natriuretic peptide (BNP) in predicting the outcome of sepsis, severe sepsis and septic shock patients.

Methods

40 patients presenting with sepsis, severe sepsis or septic were included in the study. The patients had undergone transthoracic Echocardiographic examinations and BNP measurements on the 1st and 3rd day of admission. The patients were retrospectively divided into survivors and non survivors.

Results

There was a significant statistical difference in BNP level (P = 0.0001) between the two groups. BNP showed a statistically significant rise in the non survival group from day 1 to day 3 (p = 0.002) and a statistically significant decrease from day 1 to day 3 in the survived group (p = 0.001). As regards the echo findings there was a statistically significant difference AEF 3rd day between survivors and non survivors (P = 0.0001). The ROC curve showed that BNP 1st day, 3rd day are good tests for prediction of mortality in patients with sepsis.

Conclusion

Atrial ejection force on the first day of admission, unlike BNP level, might not be used as an independent predictor of mortality in patients with sepsis. BNP level correlates with the severity of sepsis. According to our study, AEF in the third day may be a good predictor for survival of patients presenting with sepsis.

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来源期刊
自引率
0.00%
发文量
5
审稿时长
42 weeks
期刊介绍: The Egyptian Journal of Critical Care Medicine is the official Journal of the Egyptian College of Critical Care Physicians, the most authoritative organization of Egyptian physicians involved in the multi-professional field of critical care medicine. The journal is intended to provide a peer-reviewed source for multidisciplinary coverage of general acute and intensive care medicine and its various subcategories including cardiac, pulmonary, neuro, renal as well as post-operative care. The journal is proud to have an international multi-professional editorial board in the broad field of critical care that will assist in publishing promising research and breakthrough reports that lead to better patients care in life threatening conditions, and bring the reader a quick access to the latest diagnostic and therapeutic approaches in monitoring and management of critically ill patients.
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