Muhammad Taha , Sadia Sultan , Mohamad Azlan , Syed Adnan Ali Shah , Waqas Jamil , Swee Keong Yeap , Syahrul Imran , Muhammad Nadeem Akhtar , Seema Zareen , Nor Hadiani Ismail , Muhammad Ali
{"title":"一系列具有细胞毒性和抗氧化活性的6-硝基苯并呋喃-2-碳肼衍生物的合成","authors":"Muhammad Taha , Sadia Sultan , Mohamad Azlan , Syed Adnan Ali Shah , Waqas Jamil , Swee Keong Yeap , Syahrul Imran , Muhammad Nadeem Akhtar , Seema Zareen , Nor Hadiani Ismail , Muhammad Ali","doi":"10.1016/j.nhtm.2017.08.002","DOIUrl":null,"url":null,"abstract":"<div><p><span>6-nitrobenzofuran-2-carbohydrazide Schiff base derivatives have been synthesized and their structure has been confirmed </span><em>via</em> H<sup>1</sup><span><span>NMR, Mass spectrometry and elemental (CHN/S) analysis. These synthesized analogs showed significant cytotoxic and antioxidant activity. </span>Doxorubicin (IC</span><sub>50</sub> = 0.94 ± 0.20<!--> <!-->μM) and <em>n</em>-propyl gallate (IC<sub>50</sub> = 30.30 ± 0.40<!--> <!-->μM) were used as standard in cytotoxic and antioxidant activities, respectively. Compound <strong>1</strong> (IC<sub>50</sub> = 3.30 ± 0.90<!--> <!-->μM), <strong>2</strong> (IC<sub>50</sub> = 2.70 ± 0.25<!--> <!-->μM), <strong>3</strong> (IC<sub>50</sub> = 2.70 ± 0.25<!--> <!-->μM), <strong>10</strong> (IC<sub>50</sub> = 2.70 ± 1.10<!--> <!-->μM), <strong>11</strong> (IC<sub>50</sub> = 1.00 ± 1.20<!--> <!-->μM), and <strong>17</strong> (IC<sub>50</sub> = 3.75 ± 0.90<!--> <!-->μM) showed excellent while <strong>21</strong> (IC<sub>50</sub> = 7.50 ± 0.60<!--> <!-->μM) and <strong>28</strong> (IC<sub>50</sub> = 7.50 ± 0.66<!--> <span>μM) showed moderate anti cancer activity. Furthermore, compound </span><strong>10</strong> (IC<sub>50</sub> = 17.50 ± 0.85<!--> <!-->μM), <strong>11 (</strong>IC<sub>50</sub> = 24.20 ± 0.55<!--> <!-->μM), <strong>12</strong> (IC<sub>50</sub> = 21.10 ± 1.58<!--> <!-->μM), <strong>13</strong> (IC<sub>50</sub> = 14.60 ± 0.32<!--> <!-->μM), <strong>14</strong> (IC<sub>50</sub> = 29.20 ± 0.75<!--> <!-->μM) and <strong>15</strong> (IC<sub>50</sub> = 9.26 ± 0.15<!--> <!-->μM) showed better antioxidant activity than the standard <em>n</em>-propyl gallate. This study will be useful to develop potential lead molecules with cytotoxic and antioxidant potential.</p></div>","PeriodicalId":90660,"journal":{"name":"New horizons in translational medicine","volume":"4 1","pages":"Pages 23-30"},"PeriodicalIF":0.0000,"publicationDate":"2017-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.nhtm.2017.08.002","citationCount":"3","resultStr":"{\"title\":\"Synthesis of a series of new 6-nitrobenzofuran-2-carbohydrazide derivatives with cytotoxic and antioxidant activity\",\"authors\":\"Muhammad Taha , Sadia Sultan , Mohamad Azlan , Syed Adnan Ali Shah , Waqas Jamil , Swee Keong Yeap , Syahrul Imran , Muhammad Nadeem Akhtar , Seema Zareen , Nor Hadiani Ismail , Muhammad Ali\",\"doi\":\"10.1016/j.nhtm.2017.08.002\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><p><span>6-nitrobenzofuran-2-carbohydrazide Schiff base derivatives have been synthesized and their structure has been confirmed </span><em>via</em> H<sup>1</sup><span><span>NMR, Mass spectrometry and elemental (CHN/S) analysis. These synthesized analogs showed significant cytotoxic and antioxidant activity. </span>Doxorubicin (IC</span><sub>50</sub> = 0.94 ± 0.20<!--> <!-->μM) and <em>n</em>-propyl gallate (IC<sub>50</sub> = 30.30 ± 0.40<!--> <!-->μM) were used as standard in cytotoxic and antioxidant activities, respectively. Compound <strong>1</strong> (IC<sub>50</sub> = 3.30 ± 0.90<!--> <!-->μM), <strong>2</strong> (IC<sub>50</sub> = 2.70 ± 0.25<!--> <!-->μM), <strong>3</strong> (IC<sub>50</sub> = 2.70 ± 0.25<!--> <!-->μM), <strong>10</strong> (IC<sub>50</sub> = 2.70 ± 1.10<!--> <!-->μM), <strong>11</strong> (IC<sub>50</sub> = 1.00 ± 1.20<!--> <!-->μM), and <strong>17</strong> (IC<sub>50</sub> = 3.75 ± 0.90<!--> <!-->μM) showed excellent while <strong>21</strong> (IC<sub>50</sub> = 7.50 ± 0.60<!--> <!-->μM) and <strong>28</strong> (IC<sub>50</sub> = 7.50 ± 0.66<!--> <span>μM) showed moderate anti cancer activity. Furthermore, compound </span><strong>10</strong> (IC<sub>50</sub> = 17.50 ± 0.85<!--> <!-->μM), <strong>11 (</strong>IC<sub>50</sub> = 24.20 ± 0.55<!--> <!-->μM), <strong>12</strong> (IC<sub>50</sub> = 21.10 ± 1.58<!--> <!-->μM), <strong>13</strong> (IC<sub>50</sub> = 14.60 ± 0.32<!--> <!-->μM), <strong>14</strong> (IC<sub>50</sub> = 29.20 ± 0.75<!--> <!-->μM) and <strong>15</strong> (IC<sub>50</sub> = 9.26 ± 0.15<!--> <!-->μM) showed better antioxidant activity than the standard <em>n</em>-propyl gallate. This study will be useful to develop potential lead molecules with cytotoxic and antioxidant potential.</p></div>\",\"PeriodicalId\":90660,\"journal\":{\"name\":\"New horizons in translational medicine\",\"volume\":\"4 1\",\"pages\":\"Pages 23-30\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2017-11-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://sci-hub-pdf.com/10.1016/j.nhtm.2017.08.002\",\"citationCount\":\"3\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"New horizons in translational medicine\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S2307502316300558\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"New horizons in translational medicine","FirstCategoryId":"1085","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S2307502316300558","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
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