Milieu of Diabetes in the 2nd Decade of 21st Century

Diabetes mellitus, a multifactorial pathology, is a growing health problem in developed and developing countries of the modern world. Genetic, ethnic, health, dietary habit, sedentary potential, gestational abnormality in addition to other environmental stress factors are the potential stimuli for precipitating diabetic patho-physiology. The chemistry of diabetes and its milieu are multi-directional and cross-connectable. Diabetes is inter-related to hypertension, obesity, atherosclerosis, cardio-arterial disease, stroke and cancer. All these diseases can be transformed from its own pathology to other through some common axle which is still unknown. Advances in modern medicine and biotechnology are in prudent use in global research to strip up the cellular mechanism and its exploitation to bring remedies of these metabolic diseases. The probes of genetic engineering and drug modelling to find less side effects with the advents of information technology, abolition of abnormal genetic messages by DNA/RNA interference and organ grafting with regenerative prostheses by stem cell exploration are among some of the delicate devices to encounter the enmities orchestrated by the inter-locks of these dreadful diseases. This review sieves the prevailing scenario of the disease and its interventions standing in the house of advancements in second decade of this 21st century.