猫腹蛇侵袭患者炎症因子的遗传多态性

V. Tsukanov, M. Smolnikova, A. Vasyutin, E. G. Gorchilova, E. Kasparov, M.Yu. Olkhovskaya, N.O. Prokopyeva, Yu. L. Tonkikh
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摘要

目的:探讨猫腹蛇侵袭患者的实验室和仪器病理学表现与炎性细胞因子基因多态性的关系。设计。在2022年期间,我们对因猫科伊蚊入侵而住院接受致因治疗的患者进行了比较研究。材料和方法。对139例猫纹弓形虫入侵患者进行了检查。所有患者均接受临床和血液生化检查、腹部器官超声检查和肝脏弹性测量,并根据METAVIR量表评估肝纤维化。采用实时荧光定量PCR对IL28b、IL6、TNFA和IFNG基因的单核苷酸多态性进行基因分型。结果。在opisthorchasis患者中,肝纤维化与rs1800630 TNFA多态性的小等位基因A和rs2069705 IFNG的TC基因型存在相关。胆囊息肉与rs1800630 TNFA的CC基因型相关,而血液中碱性磷酸酶升高和嗜酸性粒细胞比例升高与rs2069705 IFNG的CC基因型相关。我们没有发现猫纹伊蚊入侵患者rs12979860 IL28b和rs1800795 IL6遗传多态性在研究参数上的差异。结论。应利用所得规律,提高药房观察效率,防止寄生虫入侵并发症的发生。关键词:猫腹蛇,单核苷酸多态性,细胞因子,肝纤维化
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Genetic Polymorphism of Inflammatory Cytokines in Patients with Opisthorchis felineus Invasion
Aim: To research the relationship between laboratory and instrumental manifestations of pathology and polymorphisms of inflammatory cytokine genes in patients with Opisthorchis felineus invasion. Design. During 2022, we conducted a comparative study of patients who were hospitalized for etiotropic therapy of O. felineus invasion. Materials and methods. 139 patients with O. felineus invasion were examined. All patients underwent clinical and biochemical blood tests, ultrasound of the abdominal organs and liver elastometry with an assessment of liver fibrosis according to the METAVIR scale. Genotyping of single nucleotide polymorphisms of the IL28b, IL6, TNFA, and IFNG genes was performed using real-time PCR. Results. In patients with opisthorchiasis, liver fibrosis was associated with the presence of the minor allele A of the rs1800630 TNFA polymorphism and the TC genotype of rs2069705 IFNG. Polyps in the gallbladder were associated with the CC genotype of rs1800630 TNFA, while an increase in alkaline phosphatase and an increase in the proportion of eosinophils in the blood were associated with the CC genotype of rs2069705 IFNG. We did not find differences in the studied parameters depending on the genetic polymorphisms rs12979860 IL28b and rs1800795 IL6 in patients with O. felineus invasion. Conclusion. The obtained regularities should be used to increase the efficiency of dispensary observation in order to prevent the development of complications of parasitic invasion. Keywords: Opisthorchis felineus, single nucleotide polymorphism, cytokines, liver fibrosis.
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