孟加拉国一家三级医院脊椎关节炎患者潜伏性结核感染的频率

A. T. Hasan, M. Alim
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引用次数: 0

摘要

背景与目的:建议在开始使用生物制剂和托法替尼等更有效的脊柱炎治疗方法之前筛查潜伏性结核感染。孟加拉国成年人口中潜伏结核感染的流行率尚不清楚。这个数字在印度总人口中占40%,在人口统计学上与孟加拉国人口相似。本研究的目的是评估在三级医院就诊的脊柱炎患者潜伏性结核感染的频率。材料与方法:本研究于2018年10月至2019年12月在孟加拉国达卡Savar的伊纳姆医学院和医院风湿病学系进行。75名参与者中的每一位都接受了Mantoux测试,作为检测潜伏性结核感染的筛查程序。结果:10.3%的受试者Mantoux试验阳性(≥10 mm)。在33.7%的参与者中发现读数在5到9毫米之间,其余参与者(56%)的硬结直径<5毫米。44%的受试者读数≥5毫米。结论:在参与者中发现潜伏性结核感染的频率低于预期(约40%)。但是使用5毫米的临界值产生的频率为44%,接近我们的预期。因此,对于脊椎关节炎患者的Mantoux试验的解释,较低的临界值可能是合适的。需要更大规模的研究来证实这一观察结果。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Frequency of Latent TB Infection in Patients with Spondyloarthritis in a Tertiary Care Hospital in Bangladesh
Background & Objective: Screening for latent TB infection is recommended prior to the initiation of the newer and more effective treatment modalities of spondyloathritis such as biologic agents and tofacitinib. The prevalence of latent TB infection in the adult population of Bangladesh is not yet known. The figure is 40% in the general population in India that is demographically similar to the Bangladeshi population. The objective of this study was to assess the frequency of latent TB infection in patients with spondyloarhtritis visiting a tertiary hospital. Materials & Methods: This study was conducted in the Department of Rheumatology of Enam Medical College & Hospital, Savar, Dhaka, Bangladesh from October 2018 to December 2019. Each of the 75 participants underwent Mantoux test as a screening procedure for the detection of latent TB infection. Results: Mantoux test was positive (≥10 mm) in 10.3% of the participants. A reading between 5 and 9 mm was found in 33.7% of the participants and the rest of the participants (56%) had induration diameters <5 mm). 44% of the participants had readings ≥5 mm. Conclusions: A lower than expected (around 40%) frequency of latent TB infection was found among the participants. But using a cut-off value of 5 mm yields a frequency of 44%% that is close to our expectation. So a lower cut-off value for the interpretation of Mantoux test in patients with spondyloarthritis may be appropriate. A larger-scale study is required to confirm this observation.
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