腹腔内流体流动耦合传热的计算模型

V. Simić, Jessica Domitrovic, M. Milošević, B. Milićević, A. Holder, M. Kojic
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引用次数: 0

摘要

细胞减少手术(CRS)联合腹腔高温化疗(HIPEC)已成为腹膜癌治疗的重要组成部分[1,2]。HIPEC是一种癌症治疗程序,包括将加热的化疗药物填充腹腔(也称为“热化疗”)。HIPEC是在手术切除腹部肿瘤或病变后进行的。在过去的30年里,CRS联合微小残留疾病和腹腔内化疗(IP)的方法成为一种具有长期生存潜力的方法。多种策略已被用于测量功能腹膜表面积和确定所需的灌注量。为此,我们开发了一种新的计算模型(由浸入器官的腹膜腔组成,由STL文件生成),精确计算功能腹膜表面积和腔体积(每个患者)。利用有限元程序,我们成功地模拟了腔内的传热和流体流动。此外,我们总结了速度和温度场的解,这些解是使用我们的软件包PAK和可视化的内部CAD软件获得的。目的是开发一种新的方案来计算最佳灌注量,这可以很容易地整合到术前程序中,并帮助外科医生向腹膜腔提供精确剂量的化疗。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
COMPUTATIONAL MODEL FOR HEAT TRANSFER COUPLED WITH FLUID FLOW WITHIN PERITONEAL CAVITY
Cytoreductive surgery (CRS) combined with hyperthermic intraperitoneal chemotherapy (HIPEC) has become an essential part of the management of peritoneal carcinomatosis [1,2]. HIPEC is a cancer treatment procedure that involves filling the abdominal cavity with chemotherapy drugs that have been heated (also known as “hot chemotherapy”). HIPEC is performed after the surgical procedure of removing tumors or lesions from the abdominal area. In the past 30 years, the approach of combining CRS with minimal residual disease and intraperitoneal (IP) chemotherapy emerged as one with a potential for long-term survival. Multiple strategies have been employed to measure the functional peritoneal surface area and determine the required perfusion volume. For that purpose, we have developed a novel computational model (consisted from peritoneal cavity with immersed organs, generated from STL files), with precisely calculated functional peritoneal surface area and cavity volume (for each patient). Using finite element procedure, we have managed to model a heat transfer inside the cavity, coupled with fluid flow. Further, we summarized solutions for velocity and temperature field, obtained using our software package PAK accompanied by the visualization in-house CAD software. Aim is to develop a novel protocol to calculate optimal volume of perfusion that could be easily integrated into the preoperative procedure and to help surgeons to deliver a precise dose of chemotherapy to the peritoneum cavity.
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