固体分散技术制备1,4-二氢吡啶衍生物凝胶

Proceedings of the 1st International Symposium Innovations in Life Sciences (ISILS 2019) Pub Date : 2019-11-01 DOI:10.2991/isils-19.2019.43

I. Krasnyuk, V. Grikh, A. Belyatskaya, O. I. Stepanova, V. Beketov, Galina Varenykh

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引用次数: 0

摘要

建立了一种利用固体分散技术获得1,4-二氢吡啶-硝苯地平凝胶衍生物样品的方法。对所获得的软剂型进行了质量评价。所提出的获得硝苯地平凝胶的技术的有效性已被证明，这使得有可能提高低水溶性研究物质的药物可用性，通过提高其溶解度和溶出率提供更好的释放。关键词:硝苯地平;固体分散体;凝胶;

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Development of a Derivative of 1,4-Dihydropyridine Gels Using Solid Dispersion Technique

A method has been developed for obtaining samples of a derivative of 1,4-dihydropyridine-nifedipine gels using the solid dispersion technique. A quality assessment of the obtained soft dosage forms has been performed. The effectiveness of the proposed technique for obtaining nifedipine gels has been proved, which makes it possible to increase the pharmaceutical availability of the poorly water soluble investigational substance, providing better release by increasing its solubility and dissolution rate. Keywords—nifedipine, solid dispersions, gel,

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Proceedings of the 1st International Symposium Innovations in Life Sciences (ISILS 2019)

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