α -硫辛酸作为一种潜在的疾病预防分子的分子和治疗见解。

IF 1.4 4区 医学 Q4 CHEMISTRY, MEDICINAL
Amit Kumar Tripathi, Anup Kumar Ray, Sunil Kumar Mishra, Siddharth Mall Bishen, Hirdyesh Mishra, Aman Khurana
{"title":"α -硫辛酸作为一种潜在的疾病预防分子的分子和治疗见解。","authors":"Amit Kumar Tripathi,&nbsp;Anup Kumar Ray,&nbsp;Sunil Kumar Mishra,&nbsp;Siddharth Mall Bishen,&nbsp;Hirdyesh Mishra,&nbsp;Aman Khurana","doi":"10.1007/s43450-023-00370-1","DOIUrl":null,"url":null,"abstract":"<p><p>Alpha-lipoic acid is an organic, sulfate-based compound produced by plants, humans, and animals. As a potent antioxidant and a natural dithiol compound, it performs a crucial role in mitochondrial bioenergetic reactions. A healthy human body, on the other hand, can synthesize enough α-lipoic acid to scavenge reactive oxygen species and increase endogenous antioxidants; however, the amount of α-lipoic acid inside the body decreases significantly with age, resulting in endothelial dysfunction. Molecular orbital energy and spin density analysis indicate that the sulfhydryl (-SH) group of molecules has the greatest electron donating activity, which would be responsible for the antioxidant potential and free radical scavenging activity. α-Lipoic acid acts as a chelating agent for metal ions, a quenching agent for reactive oxygen species, and a reducing agent for the oxidized form of glutathione and vitamins C and E. α-Lipoic acid enantiomers and its reduced form have antioxidant, cognitive, cardiovascular, detoxifying, anti-aging, dietary supplement, anti-cancer, neuroprotective, antimicrobial, and anti-inflammatory properties. α-Lipoic acid has cytotoxic and antiproliferative effects on several cancers, including polycystic ovarian syndrome. It also has usefulness in the context of female and male infertility. Although α-lipoic acid has numerous clinical applications, the majority of them stem from its antioxidant properties; however, its bioavailability in its pure form is low (approximately 30%). However, nanoformulations have shown promise in this regard. The proton affinity and electron donating activity, as a redox-active agent, would be responsible for the antioxidant potential and free radical scavenging activity of the molecule. This review discusses the most recent clinical data on α-lipoic acid in the prevention, management, and treatment of a variety of diseases, including coronavirus disease 2019. Based on current evidence, the preclinical and clinical potential of this molecule is discussed.</p><p><strong>Graphical abstract: </strong></p><p><strong>Supplementary information: </strong>The online version contains supplementary material available at 10.1007/s43450-023-00370-1.</p>","PeriodicalId":21196,"journal":{"name":"Revista Brasileira De Farmacognosia-brazilian Journal of Pharmacognosy","volume":null,"pages":null},"PeriodicalIF":1.4000,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9904877/pdf/","citationCount":"9","resultStr":"{\"title\":\"Molecular and Therapeutic Insights of Alpha-Lipoic Acid as a Potential Molecule for Disease Prevention.\",\"authors\":\"Amit Kumar Tripathi,&nbsp;Anup Kumar Ray,&nbsp;Sunil Kumar Mishra,&nbsp;Siddharth Mall Bishen,&nbsp;Hirdyesh Mishra,&nbsp;Aman Khurana\",\"doi\":\"10.1007/s43450-023-00370-1\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><p>Alpha-lipoic acid is an organic, sulfate-based compound produced by plants, humans, and animals. As a potent antioxidant and a natural dithiol compound, it performs a crucial role in mitochondrial bioenergetic reactions. A healthy human body, on the other hand, can synthesize enough α-lipoic acid to scavenge reactive oxygen species and increase endogenous antioxidants; however, the amount of α-lipoic acid inside the body decreases significantly with age, resulting in endothelial dysfunction. Molecular orbital energy and spin density analysis indicate that the sulfhydryl (-SH) group of molecules has the greatest electron donating activity, which would be responsible for the antioxidant potential and free radical scavenging activity. α-Lipoic acid acts as a chelating agent for metal ions, a quenching agent for reactive oxygen species, and a reducing agent for the oxidized form of glutathione and vitamins C and E. α-Lipoic acid enantiomers and its reduced form have antioxidant, cognitive, cardiovascular, detoxifying, anti-aging, dietary supplement, anti-cancer, neuroprotective, antimicrobial, and anti-inflammatory properties. α-Lipoic acid has cytotoxic and antiproliferative effects on several cancers, including polycystic ovarian syndrome. It also has usefulness in the context of female and male infertility. Although α-lipoic acid has numerous clinical applications, the majority of them stem from its antioxidant properties; however, its bioavailability in its pure form is low (approximately 30%). However, nanoformulations have shown promise in this regard. The proton affinity and electron donating activity, as a redox-active agent, would be responsible for the antioxidant potential and free radical scavenging activity of the molecule. This review discusses the most recent clinical data on α-lipoic acid in the prevention, management, and treatment of a variety of diseases, including coronavirus disease 2019. Based on current evidence, the preclinical and clinical potential of this molecule is discussed.</p><p><strong>Graphical abstract: </strong></p><p><strong>Supplementary information: </strong>The online version contains supplementary material available at 10.1007/s43450-023-00370-1.</p>\",\"PeriodicalId\":21196,\"journal\":{\"name\":\"Revista Brasileira De Farmacognosia-brazilian Journal of Pharmacognosy\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":1.4000,\"publicationDate\":\"2023-01-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9904877/pdf/\",\"citationCount\":\"9\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Revista Brasileira De Farmacognosia-brazilian Journal of Pharmacognosy\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.1007/s43450-023-00370-1\",\"RegionNum\":4,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q4\",\"JCRName\":\"CHEMISTRY, MEDICINAL\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Revista Brasileira De Farmacognosia-brazilian Journal of Pharmacognosy","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1007/s43450-023-00370-1","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q4","JCRName":"CHEMISTRY, MEDICINAL","Score":null,"Total":0}
引用次数: 9

摘要

硫辛酸是一种由植物、人类和动物产生的有机硫酸盐化合物。作为一种有效的抗氧化剂和天然二硫醇化合物,它在线粒体生物能量反应中起着至关重要的作用。另一方面,健康的人体可以合成足够的α-硫辛酸来清除活性氧和增加内源性抗氧化剂;然而,随着年龄的增长,体内α-硫辛酸的数量明显减少,导致内皮功能障碍。分子轨道能和自旋密度分析表明,巯基(-SH)分子具有最大的给电子活性,这可能是其抗氧化能力和自由基清除能力的原因。α-硫辛酸是金属离子的螯合剂,活性氧的灭活化剂,以及谷胱甘肽和维生素C、e的氧化形式的还原剂。α-硫辛酸对构象及其还原形式具有抗氧化、认知、心血管、解毒、抗衰老、膳食补充、抗癌、神经保护、抗菌和抗炎等特性。α-硫辛酸对包括多囊卵巢综合征在内的多种癌症具有细胞毒性和抗增殖作用。它在女性和男性不育的情况下也有用。虽然α-硫辛酸有许多临床应用,但大多数应用源于其抗氧化特性;然而,其纯形式的生物利用度很低(约30%)。然而,纳米配方在这方面显示出了希望。作为一种氧化还原活性物质,其质子亲和力和给电子活性决定了分子的抗氧化能力和自由基清除能力。本文综述了α-硫辛酸在包括2019冠状病毒病在内的多种疾病预防、管理和治疗中的最新临床数据。根据目前的证据,讨论了该分子的临床前和临床潜力。图片摘要:补充资料:在线版本包含补充资料,网址为10.1007/s43450-023-00370-1。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

Molecular and Therapeutic Insights of Alpha-Lipoic Acid as a Potential Molecule for Disease Prevention.

Molecular and Therapeutic Insights of Alpha-Lipoic Acid as a Potential Molecule for Disease Prevention.

Molecular and Therapeutic Insights of Alpha-Lipoic Acid as a Potential Molecule for Disease Prevention.

Molecular and Therapeutic Insights of Alpha-Lipoic Acid as a Potential Molecule for Disease Prevention.

Alpha-lipoic acid is an organic, sulfate-based compound produced by plants, humans, and animals. As a potent antioxidant and a natural dithiol compound, it performs a crucial role in mitochondrial bioenergetic reactions. A healthy human body, on the other hand, can synthesize enough α-lipoic acid to scavenge reactive oxygen species and increase endogenous antioxidants; however, the amount of α-lipoic acid inside the body decreases significantly with age, resulting in endothelial dysfunction. Molecular orbital energy and spin density analysis indicate that the sulfhydryl (-SH) group of molecules has the greatest electron donating activity, which would be responsible for the antioxidant potential and free radical scavenging activity. α-Lipoic acid acts as a chelating agent for metal ions, a quenching agent for reactive oxygen species, and a reducing agent for the oxidized form of glutathione and vitamins C and E. α-Lipoic acid enantiomers and its reduced form have antioxidant, cognitive, cardiovascular, detoxifying, anti-aging, dietary supplement, anti-cancer, neuroprotective, antimicrobial, and anti-inflammatory properties. α-Lipoic acid has cytotoxic and antiproliferative effects on several cancers, including polycystic ovarian syndrome. It also has usefulness in the context of female and male infertility. Although α-lipoic acid has numerous clinical applications, the majority of them stem from its antioxidant properties; however, its bioavailability in its pure form is low (approximately 30%). However, nanoformulations have shown promise in this regard. The proton affinity and electron donating activity, as a redox-active agent, would be responsible for the antioxidant potential and free radical scavenging activity of the molecule. This review discusses the most recent clinical data on α-lipoic acid in the prevention, management, and treatment of a variety of diseases, including coronavirus disease 2019. Based on current evidence, the preclinical and clinical potential of this molecule is discussed.

Graphical abstract:

Supplementary information: The online version contains supplementary material available at 10.1007/s43450-023-00370-1.

求助全文
通过发布文献求助,成功后即可免费获取论文全文。 去求助
来源期刊
Revista Brasileira De Farmacognosia-brazilian Journal of Pharmacognosy
Revista Brasileira De Farmacognosia-brazilian Journal of Pharmacognosy Pharmacology, Toxicology and Pharmaceutics-General Pharmacology, Toxicology and Pharmaceutics
CiteScore
2.60
自引率
12.50%
发文量
105
审稿时长
3-8 weeks
期刊介绍: The Brazilian Journal of Pharmacognosy is a scientific journal edited and published by the Brazilian Society of Pharmacognosy, an association that brings together researchers, students and professionals who study and investigate the physical, chemical and biological drugs, especially those of vegetable origin, substances isolated and such as the potential source of drugs of natural origin. It is available in printed form for its members and subscribers and openly on the Internet in all your numbers and content. The articles published are original research contributions. To evaluate the work use is made of international standards and is held by the ad hoc advisers, which reflects the quality and credibility of the journal. The BJP is published since 1986.
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
确定
请完成安全验证×
copy
已复制链接
快去分享给好友吧!
我知道了
右上角分享
点击右上角分享
0
联系我们:info@booksci.cn Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术官方微信