系统性红斑狼疮门诊患者皮质类固醇药物使用评价

M. N.Setiawati
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引用次数: 0

摘要

皮质类固醇是SLE(一种自身免疫性慢性疾病)的主要治疗方法。长期使用皮质类固醇有许多副作用的危险。本研究旨在评估SLE门诊患者使用皮质类固醇药物的情况。本研究于2017年4月至2017年8月进行。采用横断面设计,并以分析描述的方式呈现。结果:192例SLE门诊患者符合纳入标准,其中98.96%为女性。甲泼尼松是SLE门诊患者使用最多的皮质类固醇,与1种其他免疫抑制剂联合使用(65.10%),与2种其他免疫抑制剂联合使用(8.33%)。从身体质量指数来看,2605%的受试者超重,可能是因为皮质类固醇的副作用,比如体重增加。超过一半的SLE门诊患者(58.33%)由于长期使用皮质类固醇而服用补钙和维生素D3预防骨质疏松症,61例SLE门诊患者服用胃肠用药物以避免消化性溃疡。14例患者中,皮质类固醇与其他药物同时使用时可能发生相互作用,其中以皮质类固醇与阿司匹林相互作用最多。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
DRUG USE EVALUATION OF CORTICOSTEROIDSIN SYSTEMIC LUPUS ERYTHEMATOSUS OUTPATIENTS
Corticosteroids was the mainstay therapy for SLE, an autoimmune chronic desease. Prolonged use of Corticosteroid caused many side effects’ risk. This study was aimed to evaluate corticosteroid drug use in SLE outpatients. This study was conducted on April 2017 to August 2017. Cross sectional design was used and presented with analytical descriptive. The result is, 192 SLE outpatients pass the inclusion criteria and 98,96% are women. Methylprednisolon per oral is the most corticosteroid used for SLE outpatients, combine with 1 other immnunsuppresant ( 65,10  %) and combine with 2 other immunsuppresant ( 8,33% ). From  BMI, 26,05% subjects are overweight, perhaps because of corticosteroids side effect, such as weight gain. More than a half SLE outpatients (58,33%) get Calcium supplement and vitamin D3 as prophylactive for osteoporosis because of prolonged use of  corticosteroid and  61 SLE outpatients get drug for gastrointestinal use to avoid peptic ulcer. There are   44  cases of  potential corticosteroid interaction with other drug that are given together, the most are corticosteroid and aspirin interaction, on 14 patients.
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