Transition metal complexes of some compounds related to intermediates in the biosynthesis de novo of purine nucleotides

The interaction of some transition metal ions with compounds related to intermediates in the biosynthesis de novo of purine nucleotides has been examined. Crystalline complexes of copper(II) and nickel(II) with a glycineamidine ribotide (GAM) analogue have been prepared. When the GAM analogue was hydrolysed in the presence of copper(II), nickel(II), cobalt(II), or manganese(II), the normal production of substantial amounts of glycine(N-cyclohexyl)amide was not observed; the sole product was glycineamide. Analogous results were obtained with the nucleotide GAM.