长链非编码RNA在糖尿病并发症进展中调节内质网应激反应中的作用。

IF 3.8 4区医学 Q2 GENETICS & HEREDITY

Current gene therapy Pub Date : 2023-01-01 DOI:10.2174/1566523222666220801141450

Ramanarayanan Vijayalalitha, Architha Tca, George Raj Juanitaa, Ravichandran Jayasuriya, Karan Naresh Amin, Kunka Mohanram Ramkumar

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引用次数: 2

摘要

慢性高血糖会损害神经和血管，最终导致其他血管并发症。这些并发症增加了细胞因子、氧化和内质网(ER)应激。内质网是合成蛋白质的初级细胞器，并在到达目的地之前获得确认性变化。内质网稳态的扰动激活其腔内的信号传感器，即未折叠蛋白反应(UPR)，该反应协调内质网应激，并被广泛研究。据报道，在糖尿病并发症中，除了lncRNA作为上游标志物诱导内质网应激反应外，内质网应激标志物也增加。本文综述了lncRNA调节内质网应激标志物的机制，特别是在糖尿病并发症的进展过程中。通过这一系统综述，我们展示了功能失调的lncrna在糖尿病并发症进展中作为内质网应激反应的主要原因。

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Role of Long Non-Coding RNA in Regulating ER Stress Response to the Progression of Diabetic Complications.

Chronic hyperglycemia damages the nerves and blood vessels, culminating in other vascular complications. Such complications enhance cytokine, oxidative and endoplasmic reticulum (ER) stress. ER is the primary organelle where proteins are synthesised and attains confirmatory changes before its site of destination. Perturbation of ER homeostasis activates signaling sensors within its lumen, the unfolded protein response (UPR) that orchestrates ER stress and is extensively studied. Increased ER stress markers are reported in diabetic complications in addition to lncRNA that acts as an upstream marker inducing ER stress response. This review focuses on the mechanisms of lncRNA that regulate ER stress markers, especially during the progression of diabetic complications. Through this systemic review, we showcase the dysfunctional lncRNAs that act as a leading cause of ER stress response to the progression of diabetic complications.

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来源期刊

Current gene therapy 医学-遗传学

CiteScore

6.70

自引率

2.80%

发文量

期刊介绍： Current Gene Therapy is a bi-monthly peer-reviewed journal aimed at academic and industrial scientists with an interest in major topics concerning basic research and clinical applications of gene and cell therapy of diseases. Cell therapy manuscripts can also include application in diseases when cells have been genetically modified. Current Gene Therapy publishes full-length/mini reviews and original research on the latest developments in gene transfer and gene expression analysis, vector development, cellular genetic engineering, animal models and human clinical applications of gene and cell therapy for the treatment of diseases. Current Gene Therapy publishes reviews and original research containing experimental data on gene and cell therapy. The journal also includes manuscripts on technological advances, ethical and regulatory considerations of gene and cell therapy. Reviews should provide the reader with a comprehensive assessment of any area of experimental biology applied to molecular medicine that is not only of significance within a particular field of gene therapy and cell therapy but also of interest to investigators in other fields. Authors are encouraged to provide their own assessment and vision for future advances. Reviews are also welcome on late breaking discoveries on which substantial literature has not yet been amassed. Such reviews provide a forum for sharply focused topics of recent experimental investigations in gene therapy primarily to make these results accessible to both clinical and basic researchers. Manuscripts containing experimental data should be original data, not previously published.