蛋白质和囊泡运输

Science's STKE Pub Date : 2001-12-04 DOI:10.1126/scisignal.1112001tw447

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引用次数: 0

摘要

衰减手机信号与诱导手机信号同样重要。例如，G蛋白信号调节蛋白(RGS)调节受体偶联异三聚体G蛋白的信号输出。Zheng等人(见von Zastrow和Mostov的观点)已经确定了Gαs类G蛋白的难以捉摸的RGS。它被命名为RGS-PX1，还包含一个与膜相互作用的PhoX结构域，其存在表明G蛋白信号传导与细胞中囊泡运输之间存在联系。郑B.， yyc .。马，R. S. Ostrom, C. Lavoie, G. N. Gill, P. A. Insel, x.y。黄明辉，黄明辉，黄明辉，RGS-PX1, g - α - s与分选连接蛋白在囊泡转运中的GAP。科学294,1939-1942(2001)。[摘要]M. von Zastrow, K. Mostov，复杂网络中的新线索。科学294,1845-1847(2001)。(全文)

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G Proteins and Vesicle Trafficking

Attenuating a cellular signal is just as critical as inducing it. For example, regulator of G protein signaling (RGS) proteins modulate the signaling output from receptor-coupled heterotrimeric G proteins. Zheng et al. (see the Perspective by von Zastrow and Mostov) have identified what has been an elusive RGS for the Gαs class of G proteins. Named RGS-PX1, it also contains a membrane-interacting PhoX domain whose presence suggests a link between G protein signaling and vesicle trafficking in cells. B. Zheng, Y.-C. Ma, R. S. Ostrom, C. Lavoie, G. N. Gill, P. A. Insel, X.-Y. Huang, M. G. Farquhar, RGS-PX1, a GAP for Gαs and sorting nexin in vesicular trafficking. Science 294, 1939-1942 (2001). [Abstract] [Full Text] M. von Zastrow, K. Mostov, A new thread in an intricate web. Science 294, 1845-1847 (2001). [Full Text]

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