Comparative Double Blind Clinical Trial Study of Side Effects of Areca catechu L., TTHF, and Mebendazole, in Treatment of Human Mixed Worm Infection

This study was carried out in Mahasarakham Primary Healthcare Centre, Mahasarakham province in the area of Northeastern of Thailand. The experiment was carried on with 200   samples  with  randomized control trial clinical study in order to examine the side effects of Areca catechu Linn., TTHF and  Mebendazole  after the treatment of antihelmintic activity of mixed worms infection in human . The 3 experimental groups consisted of 50 patients in each group and 50 patients for control group testing with placebo with inclusion and exclusion criteria which were screened by parasitologist of mixed worm infection symptoms samples. The investigation  of side effects were investigated after treating the first dose of Areca catechu Linn, TTHF and Mebendazole which were confirmed by the physician and the pharmacist. The side effects data were collected before and after the treatment with Areca catechu Linn. and with placebo. The result showed that Areca catechu Linn. had 20% of diarrhea and 20% of nausea, 20% of diarrhea in Mebendazole  and 0% in TTHF. The suggestion of this study should increase the number of samples of worm infected patients and also the numbers of locations in Thailand  in order to obtain various kinds of helminthes. Key words: TTHF (Thai Traditional  Herbal  Formula); Mebendazole; Areca catechu Linn.; Side effects; Antihelmintic activity