血小板在病毒性出血热中的作用

D. Cox, M. Salvato, J. Zapata
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引用次数: 7

摘要

很难确定病原体,因为大多数甚高频都有类似的表现。即使有可用的抗病毒药物,它们也不可能对所有的药物都有效,因为这些病毒来自不同的科。然而,所有这些病毒的一个共同因素是它们能够逃避先天免疫系统并损害血小板功能。因此,血小板是治疗vhf的潜在药物靶点。因此,研究血小板在VHF发病机制中的作用可能会导致发现新的药物靶点,不仅可以抑制病毒复制,还可以提高抗病毒免疫反应,防止出血性疾病的发生。虽然靶向血小板可能不能抑制病毒复制,但它可能为免疫系统清除病毒提供时间,从而防止出血热的发生。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
The Role of Platelets in Viral Hemorrhagic Fevers
very difficult to identify the causative agent, as most VHFs have similar presentations. Even if there were anti-viral agents available, they would be unlikely to be effective against all agents, as the viruses are from different families. However, a common factor with all of these viruses is their ability to evade the innate immune system and compromise platelet function. Thus, platelets are a potential drug target in the treatment of VHFs. Therefore, the study of the role of platelets in the VHF pathogenesis may lead to the identification of new drug targets that will not only inhibit viral replication, but will also improve the antiviral immune response, preventing the onset of the hemorrhagic disease. While targeting the platelet may not inhibit viral replication, it may provide time for the immune system to clear the virus, and thereby, preventing the onset of hemorrhagic fever.
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