Yahya Salma, H. Zakaria, I. Hassan, M. Bouchekara, H. El-Nakat, F. Omar, A. Allouch
{"title":"一种新型外消旋硫脲底物配合物的分光光度法研究及atropisomer的分离","authors":"Yahya Salma, H. Zakaria, I. Hassan, M. Bouchekara, H. El-Nakat, F. Omar, A. Allouch","doi":"10.7439/IJPC.V8I1.4681","DOIUrl":null,"url":null,"abstract":"The activity of a chiral molecule can vary from one atropisomer to the other. In this study, the separation of racemic-N-(2-methylphenyl), N’-(2-chlorophenyl) thiourea (H 2 L 2 ), a hydrophobic heavy metal trap, has been studied using reversed-phase high-performance liquid chromatography (RP-HPLC) with hydroxypropyl-beta-cyclodextrin (HP-β-CD) as a complexing additive to the racemic mixture and hexane-isopropanol as a mobile phase. The stoichiometry and the overall association constant of the complex have been determined using the continuous variation (Job's plot) method and the Scott's method respectively.","PeriodicalId":14317,"journal":{"name":"International Journal of Pharmaceutical Chemistry","volume":"56 1","pages":"01-06"},"PeriodicalIF":0.0000,"publicationDate":"2018-04-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Complex of a new racemic thiourea substrate: Spectrophotometric study and separation of atropisomers\",\"authors\":\"Yahya Salma, H. Zakaria, I. Hassan, M. Bouchekara, H. El-Nakat, F. Omar, A. Allouch\",\"doi\":\"10.7439/IJPC.V8I1.4681\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"The activity of a chiral molecule can vary from one atropisomer to the other. In this study, the separation of racemic-N-(2-methylphenyl), N’-(2-chlorophenyl) thiourea (H 2 L 2 ), a hydrophobic heavy metal trap, has been studied using reversed-phase high-performance liquid chromatography (RP-HPLC) with hydroxypropyl-beta-cyclodextrin (HP-β-CD) as a complexing additive to the racemic mixture and hexane-isopropanol as a mobile phase. The stoichiometry and the overall association constant of the complex have been determined using the continuous variation (Job's plot) method and the Scott's method respectively.\",\"PeriodicalId\":14317,\"journal\":{\"name\":\"International Journal of Pharmaceutical Chemistry\",\"volume\":\"56 1\",\"pages\":\"01-06\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2018-04-19\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"International Journal of Pharmaceutical Chemistry\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.7439/IJPC.V8I1.4681\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"International Journal of Pharmaceutical Chemistry","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.7439/IJPC.V8I1.4681","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
Complex of a new racemic thiourea substrate: Spectrophotometric study and separation of atropisomers
The activity of a chiral molecule can vary from one atropisomer to the other. In this study, the separation of racemic-N-(2-methylphenyl), N’-(2-chlorophenyl) thiourea (H 2 L 2 ), a hydrophobic heavy metal trap, has been studied using reversed-phase high-performance liquid chromatography (RP-HPLC) with hydroxypropyl-beta-cyclodextrin (HP-β-CD) as a complexing additive to the racemic mixture and hexane-isopropanol as a mobile phase. The stoichiometry and the overall association constant of the complex have been determined using the continuous variation (Job's plot) method and the Scott's method respectively.
求助内容：
应助结果提醒方式：
京公网安备 11010802042870号
