{"title":"骨关节炎:从未来的治疗到未来的治疗","authors":"Vianney Delplace , Marie-Astrid Boutet , Catherine Le Visage , Yves Maugars , Jérôme Guicheux , Claire Vinatier","doi":"10.1016/j.monrhu.2020.12.004","DOIUrl":null,"url":null,"abstract":"<div><p>Osteoarthritis affects hundreds of millions of people worldwide, and its prevalence is constantly increasing. While there is no effective treatment to date, new promising therapeutic strategies and targets are being investigated. Innovative cell therapies are reaching clinical trials, and the most recent progress in our understanding of the pathology is opening new routes for gene therapy. In the long term, the development of new biofabrication tools such as 3D bioprinting might pave the way for the use of personalized mini-joint models that would allow clinicians to screen drugs and personalize treatments. This review offers an overview of the most promising therapeutic approaches in the field of osteoarthritis, from coming treatments to those that are yet to be discovered.</p></div>","PeriodicalId":101125,"journal":{"name":"Revue du Rhumatisme Monographies","volume":null,"pages":null},"PeriodicalIF":0.0000,"publicationDate":"2021-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.monrhu.2020.12.004","citationCount":"0","resultStr":"{\"title\":\"Arthrose : des traitements à venir aux traitements d’avenir\",\"authors\":\"Vianney Delplace , Marie-Astrid Boutet , Catherine Le Visage , Yves Maugars , Jérôme Guicheux , Claire Vinatier\",\"doi\":\"10.1016/j.monrhu.2020.12.004\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><p>Osteoarthritis affects hundreds of millions of people worldwide, and its prevalence is constantly increasing. While there is no effective treatment to date, new promising therapeutic strategies and targets are being investigated. Innovative cell therapies are reaching clinical trials, and the most recent progress in our understanding of the pathology is opening new routes for gene therapy. In the long term, the development of new biofabrication tools such as 3D bioprinting might pave the way for the use of personalized mini-joint models that would allow clinicians to screen drugs and personalize treatments. This review offers an overview of the most promising therapeutic approaches in the field of osteoarthritis, from coming treatments to those that are yet to be discovered.</p></div>\",\"PeriodicalId\":101125,\"journal\":{\"name\":\"Revue du Rhumatisme Monographies\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2021-04-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://sci-hub-pdf.com/10.1016/j.monrhu.2020.12.004\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Revue du Rhumatisme Monographies\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S1878622720301351\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Revue du Rhumatisme Monographies","FirstCategoryId":"1085","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S1878622720301351","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
Arthrose : des traitements à venir aux traitements d’avenir
Osteoarthritis affects hundreds of millions of people worldwide, and its prevalence is constantly increasing. While there is no effective treatment to date, new promising therapeutic strategies and targets are being investigated. Innovative cell therapies are reaching clinical trials, and the most recent progress in our understanding of the pathology is opening new routes for gene therapy. In the long term, the development of new biofabrication tools such as 3D bioprinting might pave the way for the use of personalized mini-joint models that would allow clinicians to screen drugs and personalize treatments. This review offers an overview of the most promising therapeutic approaches in the field of osteoarthritis, from coming treatments to those that are yet to be discovered.