The multifunctional nano-immunoliposome design: hypothesis on a therapeutic approach for COVID-19

Abstract The article presents a hypothesis on a co-delivery strategy to suppress or reduce infection caused by the COVID-19 virus. Co-delivery was illustrated in many diseases, and results showed that it produced a high therapeutic efficacy against disorders. We proposed an approach to suppress or reduce infection caused by the coronavirus disease 2019 via designing an intelligent nano-liposome loaded with interferon γ, interleukin 4 and small interfering RNA against vimentin. At the surface of this nanostructure, there is a matrix metallopeptidase3 substrate to provide a platform for the enzymatic function of matrix metallopeptidase3 to destroy the extracellular matrix, angiotensin-converting enzyme 2 blocker, and antibody against vimentin for targeting, trans-activator of transcription peptide, and polyethylene glycol. Due to the increasing application of nano-liposomes commercially as a drug-delivery system, it is important to consider this effective approach for the coronavirus disease 2019 treatment. Graphical Abstract