APOE4 等位基因和性别对阿尔茨海默病海马、内顶皮层和纺锤形回萎缩速度的影响

IF 1.8 4区医学 Q3 CLINICAL NEUROLOGY

Current Alzheimer research Pub Date : 2023-03-09 DOI:10.2174/1567205020666230309113749

Eid Abo Hamza, Ahmed A Moustafa, Richard Tindle, Rasu Karki, Shahed Nalla, Mohamed S Hamid, Mohamad El Haj

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引用次数: 0

摘要

背景海马、内侧皮层和纺锤形回是阿尔茨海默病（AD）早期恶化的脑区。载脂蛋白E4等位基因已被确定为阿尔茨海默病发病的风险因素，与大脑中淀粉样蛋白ß（Aß）斑块聚集的增加有关，并导致海马区萎缩。然而，据我们所知，目前还没有人研究过带有或不带有载脂蛋白E4等位基因的AD患者随着时间推移病情恶化的速度：在这项研究中，我们首次利用阿尔茨海默病神经影像学倡议（ADNI）数据集分析了有载脂蛋白E4和没有载脂蛋白E4的AD患者这些脑结构的萎缩情况：结果：我们发现，这些脑区的体积在12个月内的减少率与载脂蛋白E4的存在有关。此外，我们还发现，与之前的研究不同，女性和男性患者的神经萎缩并无差异，这表明载脂蛋白E4的存在与AD的性别差异无关：我们的研究结果证实并扩展了之前的研究结果，表明载脂蛋白E4等位基因会逐渐影响受AD影响的大脑区域。

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Effect of APOE4 Allele and Gender on the Rate of Atrophy in the Hippocampus, Entorhinal Cortex, and Fusiform Gyrus in Alzheimer's Disease.

Background: The hippocampus, entorhinal cortex, and fusiform gyrus are brain areas that deteriorate during early-stage Alzheimer's disease (AD). The ApoE4 allele has been identified as a risk factor for AD development, is linked to an increase in the aggregation of amyloid ß (Aß) plaques in the brain, and is responsible for atrophy of the hippocampal area. However, to our knowledge, the rate of deterioration over time in individuals with AD, with or without the ApoE4 allele, has not been investigated.

Method: In this study, we, for the first time, analyze atrophy in these brain structures in AD patients with and without the ApoE4 using the Alzheimer's Disease Neuroimaging Initiative (ADNI) dataset.

Results: It was found that the rate of decrease in the volume of these brain areas over 12 months was related to the presence of ApoE4. Further, we found that neural atrophy was not different for female and male patients, unlike prior studies, suggesting that the presence of ApoE4 is not linked to the gender difference in AD.

Conclusion: Our results confirm and extend previous findings, showing that the ApoE4 allele gradually impacts brain regions impacted by AD.

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来源期刊

Current Alzheimer research 医学-神经科学

CiteScore

4.00

自引率

4.80%

发文量

审稿时长

4-8 weeks

期刊介绍： Current Alzheimer Research publishes peer-reviewed frontier review, research, drug clinical trial studies and letter articles on all areas of Alzheimer’s disease. This multidisciplinary journal will help in understanding the neurobiology, genetics, pathogenesis, and treatment strategies of Alzheimer’s disease. The journal publishes objective reviews written by experts and leaders actively engaged in research using cellular, molecular, and animal models. The journal also covers original articles on recent research in fast emerging areas of molecular diagnostics, brain imaging, drug development and discovery, and clinical aspects of Alzheimer’s disease. Manuscripts are encouraged that relate to the synergistic mechanism of Alzheimer''s disease with other dementia and neurodegenerative disorders. Book reviews, meeting reports and letters-to-the-editor are also published. The journal is essential reading for researchers, educators and physicians with interest in age-related dementia and Alzheimer’s disease. Current Alzheimer Research provides a comprehensive ''bird''s-eye view'' of the current state of Alzheimer''s research for neuroscientists, clinicians, health science planners, granting, caregivers and families of this devastating disease.