骨支架在单轴和双轴压缩载荷下的制备、实验研究和二维有限元计算均质化

IF 4.2 Q2 NANOSCIENCE & NANOTECHNOLOGY
A. Khalvandi, Mohammad Mohammadi Aghdam, S. Saber-Samandari
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引用次数: 3

摘要

本研究利用冷冻干燥法制备了一种新型的由明胶和聚吡咯生物聚合物以及阿克曼石和磁铁矿生物陶瓷组成的纳米复合骨支架。采用傅里叶变换红外光谱(FTIR)和x射线衍射(XRD)分析。确定了现有的官能团和晶相。显微成像,平均孔细胞大小为165.62µm。根据液体置换法的结果,孔隙度为68%±3%。制备的支架在140 h内最大膨胀率为1012%。监测生物活性,显微镜下观察形成的磷灰石层。成骨细胞培养后进行MTT实验,3天后记录细胞存活率100%。采用改进的随机顺序吸附(mRSA)算法生成二维多孔多相代表体积元(RVEs)。然后,我们在rve的边界上施加周期性边界条件。双轴压缩时,沿x轴的均质弹性模量为14.81 kPa。在此加载状态下,沿y轴均质杨氏模量为13.7 kPa。单轴加载下y轴方向均匀杨氏模量为12.54 kPa。根据微力学建模结果,观察到这种支架的非各向同性行为。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Fabrication, experimental study, and 2-D finite element computational homogenization of bone scaffolds under uniaxial and biaxial compressive loadings
In this research, a novel nanocomposite bone scaffold made up of Gelatin and Polypyrrole biopolymers and Akermanite and Magnetite bioceramics was fabricated utilizing the freeze-drying method. Fourier Transform Infrared (FTIR) spectroscopy and X-ray Diffraction (XRD) analysis were employed. The existing functional groups and crystalline phases were identified. Microscopic images were taken, and the mean pore cell size was 165.62 µm. According to the results of the liquid displacement method, the porosity was 68% ± 3%. The fabricated scaffolds showed maximum swelling of 1012% during 140 h. The bioactivity was monitored, and the formed Apatite layers were seen in microscopic images. The MTT assay was conducted by Osteoblast cells culture, and after 3 days, 100% cell viability was recorded. 2-D porous multiphase Representative Volume Elements (RVEs) were generated employing the modified Random Sequential Adsorption (mRSA) algorithm. Afterward, we imposed periodic boundary conditions on the boundaries of the RVEs. The homogenized elastic modulus along the X-axis was 14.81 kPa in biaxial compression. In this loading state, homogenized Young’s modulus along the Y-axis was 13.7 kPa. Homogenized Young’s modulus along Y-axis direction under uniaxial loading was 12.54 kPa. According to the micromechanical modeling results, non-isotropic behavior from such scaffolds was seen.
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来源期刊
CiteScore
6.00
自引率
1.70%
发文量
24
期刊介绍: Proceedings of the Institution of Mechanical Engineers Part N-Journal of Nanomaterials Nanoengineering and Nanosystems is a peer-reviewed scientific journal published since 2004 by SAGE Publications on behalf of the Institution of Mechanical Engineers. The journal focuses on research in the field of nanoengineering, nanoscience and nanotechnology and aims to publish high quality academic papers in this field. In addition, the journal is indexed in several reputable academic databases and abstracting services, including Scopus, Compendex, and CSA's Advanced Polymers Abstracts, Composites Industry Abstracts, and Earthquake Engineering Abstracts.
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