用胶原蛋白的肽质量指纹图谱测量的骨组合中谷氨酰胺脱酰胺的变化

F. Welker, M. Soressi, Morgan Roussel, I. van Riemsdijk, J. Hublin, M. Collins
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引用次数: 39

摘要

骨胶原肽质量指纹图谱(ZooMS)已被提出作为一种计算谷氨酰胺非酶降解成谷氨酸(脱酰胺)程度的方法。然而,谷氨酰胺脱酰胺在单一位点的时空变化尚未被研究。本文采用ZooMS技术对法国quinay地区的早期全新世骨标本进行筛选,探讨谷氨酰胺脱酰胺的时空变化。结果表明,时间分辨率较低,空间差异较大。然而,我们的分析允许鉴定的骨标本经历了显著不同的成岩历史(无论是在长度或类型)从空间相关的骨标本。因此,ZooMS的碳酸氢铵筛选能够检测骨组合的均匀性,从而指导后续的分析和解释。图形抽象
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Variations in glutamine deamidation for a Châtelperronian bone assemblage as measured by peptide mass fingerprinting of collagen
Abstract Peptide mass fingerprinting of bone collagen (ZooMS) has previously been proposed as a method to calculate the extent of the non-enzymatic degradation of glutamine into glutamic acid (deamidation). Temporal and spatial variation of glutamine deamidation at a single site, however, has not been investigated. Here we apply ZooMS screening of Châtelperronian and Early Holocene bone specimens from Quinçay, France, to explore temporal and spatial variation in glutamine deamidation. Our results indicate that chronological resolution is low, while spatial variation is high. Nevertheless, our analysis allows the identification of bone specimens that have undergone diagenetic histories remarkably different (either in length or in type) from spatially related bone specimens. Therefore, ZooMS ammonium-bicarbonate screening is capable of testing bone assemblage homogeneity, which could guide subsequent analysis and interpretation. GRAPHICAL ABSTRACT
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