肾与高钙血症的双向之路:述评。

Q2 Medicine

Cardiovascular and Hematological Disorders - Drug Targets Pub Date : 2023-01-01 DOI:10.2174/1871529X23666221205143041

Ziba Aghsaeifard, Reza Alizadeh

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引用次数: 0

摘要

钙稳态是由甲状旁腺激素和骨化三醇共同调节的，而肾、肠和骨是主要的靶部位。血清钙水平升高和高钙血症可能是病理状况的标志，特别是恶性肿瘤和甲状旁腺功能亢进。同样，体内的一些功能障碍也可以引起高钙血症。此外，化学物质和药物也会导致这种情况。由于肾脏在钙稳态中的重要作用，肾脏异常可导致高钙血症，钙水平升高可对肾脏产生病理影响。这篇综述旨在强调一些常见的高钙血症的原因及其对肾脏的影响。

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Two-way Road of Kidney and Hypercalcemia: A Narrative Review.

Calcium homeostasis is regulated by the dyad of parathyroid hormone and calcitriol, whereas kidney, intestine, and bone are the primary target sites. Elevation of serum calcium levels and hypercalcemia are likely markers of pathological conditions, particularly malignancy and hyperparathyroidism. Similarly, several dysfunctions within the body can direct hypercalcemia. Furthermore, chemicals and drugs can also drive this condition. Owing to the significant role of the kidney in calcium homeostasis, renal abnormalities lead to hypercalcemia and increased calcium levels can have pathological effects on the kidney. This review is designed to highlight some of the commonly known causes of hypercalcemia and their effects on the kidney.

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来源期刊

Cardiovascular and Hematological Disorders - Drug Targets Medicine-Cardiology and Cardiovascular Medicine

CiteScore

1.90

自引率

0.00%

发文量

期刊介绍： Cardiovascular & Hematological Disorders - Drug Targets aims to cover all the latest and outstanding developments on the medicinal chemistry, pharmacology, molecular biology, genomics and biochemistry of contemporary molecular targets involved in cardiovascular and hematological disorders e.g. disease specific proteins, receptors, enzymes, genes. Each issue of the journal contains a series of timely in-depth reviews written by leaders in the field covering a range of current topics on drug targets involved in cardiovascular and hematological disorders. As the discovery, identification, characterization and validation of novel human drug targets for cardiovascular and hematological drug discovery continues to grow.