可乐定与右美托咪定对喉镜和插管后应激反应衰减的比较研究

Divya, Karthikeya Jampala, K. Radhika
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摘要

背景:气管插管可引起多种心血管并发症。有时这些并发症会导致死亡。插管前尝试各种麻醉药物以减少血流动力学变化。本研究旨在评价可乐定与右美托咪定在喉镜检查和插管后的应激反应的衰减。材料和方法:研究在印度喀拉拉邦特里凡得琅的Sree Gokulam医学院麻醉科和研究基金会完成。本研究共纳入50例患者,根据纳入和排除标准,分为两组,每组25例。G-I组给予可乐定(2mcg/kg), G-II组给予右美托咪定(0.5mcg/kg)。诱导前10分钟给药。记录人口统计学数据(年龄和性别)和临床数据(心率、收缩压、舒张压和MAP)。采用SPSS(20.0)版本进行分析。结果:i组与II组人口学资料比较无显著性差异。i组与II组平均心率比较无明显差异。SBP (PI, AL)、DBP (PI)、MAP (PI)在i组与II组比较差异有统计学意义。结论:右旋美托咪定在喉镜插管前10分钟给予0.5µg/kg剂量比可乐定更能降低喉镜插管后的血流动力学反应。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
A comparative study of clonidine versus dexmedetomidine in attenuation of stress response to laryngoscopy and intubation
Background: Endotracheal intubation produces various cardio vascular complications. Sometimes these complications lead to mortality. Various anaesthetic drugs are tried before intubation to reduce the haemodynamic changes. The present study aimed to evaluate the clonidine versus dexmedetomidine in attenuation of stress response to laryngoscopy and intubation. Materials and Methods: The study was done in Department of Anaesthesia , Sree Gokulam Medical College and Research Foundation, Trivandrum, Kerala. A total of 50 patients included in the study based on the inclusion and exclusion criteria and divided into two group each of 25. G-I received Clonidine (2mcg/kg) and G-II Dexmedetomidine (0.5mcg/kg). Drugs are given to respective groups 10 min before induction. Demographic data (age and gender) and clinical data (heart rate, SBP, DBP and MAP) was recorded. SPSS (20.0) version was used for analysis. Results: Group-I and II not showed any significant difference on comparison of demographic data. Comparison of mean heart rate between the group-I and II not showed any significant difference. SBP (PI, AL), DBP (PI) and MAP (PI) showed significant difference when compared between the group-I and II. Conclusion: Dexmedetomidine in the dose of 0.5µg/kg, given 10 minutes before laryngoscopy and intubation is better choice than clonidine in attenuating the haemodynamic responses to laryngoscopy and intubation.
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