2型糖尿病患者血清网膜蛋白-1水平及其与肥胖的关系

Y. Abdullatif, Karima Y. Ahmed, Fatma M. El-Senosy, Rasha Mohammed Abd El-Aziz
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引用次数: 0

摘要

糖尿病(DM)是一种复杂的代谢性疾病,在世界范围内迅速出现,已被列为流行病。目的提高人们对网膜蛋白-1及其与2型糖尿病、胰岛素抵抗和肥胖之间关系的认识。患者与方法本研究纳入50例年龄在40 ~ 70岁的2型糖尿病患者,分为两组(肥胖组25例,非肥胖组25例)和40组(肥胖组20例,非肥胖组20例)相匹配的患者作为对照组。各组均进行全部病史和临床检查(空腹血糖、总胆固醇、甘油三酯、低密度脂蛋白-胆固醇、糖化血红蛋白、空腹胰岛素、血清网膜蛋白-1水平)。测量了体重和身高。计算体内平衡模型评估胰岛素抵抗和BMI。结果与对照组相比,2型糖尿病患者血清网膜蛋白-1水平明显降低。血清网膜蛋白-1水平与肥胖、胰岛素抵抗和收缩压呈负相关。血清omentin-1水平与空腹血糖、糖化血红蛋白和空腹血脂水平呈负相关。结论Omentin-1可作为肥胖及相关代谢和血管疾病的生物标志物。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Serum omentin-1 levels in type II diabetes and its relationship with obesity
Background Diabetes mellitus (DM) is a complex metabolic disorder, and its rapid emergence worldwide has led to its classification as an epidemic. Aim To increase our knowledge about omentin-1 and its relation with type 2 DM, insulin resistance, and obesity. Patients and methods This study included 50 patients with type 2 DM, with an age range from 40 to 70 years, who were divided into two groups (25 obese and 25 nonobese), as well as 40 age group (20 obese and 20 nonobese)-matched patients, who formed the control group. Each group was subjected to full history taking and clinical examination (fasting blood glucose, total cholesterol, triglycerides, low-density lipoprotein-cholesterol, glycosylated hemoglobin, fasting insulin, and serum omentin-1 levels). Weight and height were measured. Homeostasis model assessment insulin resistance and BMI were calculated. Results The study showed a significant decrease in serum omentin-1 levels in type 2 diabetic patients in comparison with the control group. Serum omentin-1 levels inversely correlated with obesity, insulin resistance, and systolic blood pressure. Negative associations were found between serum omentin-1 level and fasting glucose, glycosylated hemoglobin, and fasting lipid levels. Conclusion Omentin-1 may be used as a biomarker for obesity and associated metabolic and vascular disorders.
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