糖尿病诺卡菌致脑脓肿1例报告。

IF 2.5 3区 工程技术 Q2 BIOLOGY
Yale Journal of Biology and Medicine Pub Date : 2022-12-01
Hossein Ali Rahdar, Hamid Heidari, Morteza Karami-Zarandi, Tahereh Soori, Parisa Asadollahi, Hossein Kazemian
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引用次数: 0

摘要

无心性脑脓肿通常与免疫缺陷有关,但有时也会出现在健康个体中。这种感染可以通过吸入或直接接种细菌获得,然后通过血液循环传播到包括大脑在内的各个器官。无心性脑脓肿的死亡率是其他细菌引起的脑脓肿的3倍。此外,与其他诺卡菌引起的脑脓肿相比,与小行星诺卡菌相关的脑脓肿患者预后较差,这可能是由于小行星诺卡菌对多种抗生素具有较高的耐药倾向。因此,尽早诊断和治疗脑脓肿是至关重要的。本文罕见报道1例糖尿病患者发生由N. asteroides引起的脑脓肿,多种抗生素(甲氧苄啶/磺胺甲恶唑和阿米卡星)治疗无效,经亚胺培南和利奈唑胺治疗后病情好转,最终通过手术和长期抗生素(亚胺培南和利奈唑胺)治疗成功。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

Brain Abscess Caused by <i>Nocardia asteroides</i> in a Diabetic Patient: A Rare Case Report.

Brain Abscess Caused by <i>Nocardia asteroides</i> in a Diabetic Patient: A Rare Case Report.

Brain Abscess Caused by Nocardia asteroides in a Diabetic Patient: A Rare Case Report.

Nocardial brain abscess is usually associated with immunodeficiency, but can sometimes emerge in healthy individuals. This infection can be acquired through inhalation or direct inoculation of the bacteria, followed by dissemination to various organs, including the brain, through blood circulation. Mortality rate due to nocardial cerebral abscess is three times higher than that associated with cerebral abscess caused by other types of bacteria. Moreover, patients with Nocardia asteroides-associated brain abscess show poorer prognosis compared to patients with brain abscess caused by other Nocardia species, which is probably due to the high tendency of N. asteroides to become resistant to numerous antibiotics. It is, therefore, of paramount importance to diagnose and treat N. asteroides cerebral abscess in patients as soon as possible. The current paper is a rare report of a brain abscess caused by N. asteroides in a diabetic patient who failed to respond to multiple antibiotics (trimethoprim/sulfamethoxazole and amikacin), but improved by receiving imipenem and linezolid, and was finally successfully treated by surgical operation and long-term antibiotic therapy (imipenem and linezolid).

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来源期刊
Yale Journal of Biology and Medicine
Yale Journal of Biology and Medicine Biochemistry, Genetics and Molecular Biology-General Biochemistry,Genetics and Molecular Biology
CiteScore
5.00
自引率
0.00%
发文量
41
期刊介绍: The Yale Journal of Biology and Medicine (YJBM) is a graduate and medical student-run, peer-reviewed, open-access journal dedicated to the publication of original research articles, scientific reviews, articles on medical history, personal perspectives on medicine, policy analyses, case reports, and symposia related to biomedical matters. YJBM is published quarterly and aims to publish articles of interest to both physicians and scientists. YJBM is and has been an internationally distributed journal with a long history of landmark articles. Our contributors feature a notable list of philosophers, statesmen, scientists, and physicians, including Ernst Cassirer, Harvey Cushing, Rene Dubos, Edward Kennedy, Donald Seldin, and Jack Strominger. Our Editorial Board consists of students and faculty members from Yale School of Medicine and Yale University Graduate School of Arts & Sciences. All manuscripts submitted to YJBM are first evaluated on the basis of scientific quality, originality, appropriateness, contribution to the field, and style. Suitable manuscripts are then subject to rigorous, fair, and rapid peer review.
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