淋病奈瑟菌阿奇霉素和红霉素耐药率的全球现状:系统回顾和荟萃分析。

IF 2.5 3区 工程技术 Q2 BIOLOGY
Yale Journal of Biology and Medicine Pub Date : 2022-12-01
Zhiwei Lu, Danyal Abbasi Tadi, Jinchao Fu, Khalil Azizian, Ebrahim Kouhsari
{"title":"淋病奈瑟菌阿奇霉素和红霉素耐药率的全球现状:系统回顾和荟萃分析。","authors":"Zhiwei Lu,&nbsp;Danyal Abbasi Tadi,&nbsp;Jinchao Fu,&nbsp;Khalil Azizian,&nbsp;Ebrahim Kouhsari","doi":"","DOIUrl":null,"url":null,"abstract":"<p><p><b>Background</b>: The widespread development of antibiotic resistance or decreased susceptibility in <i>Neisseria gonorrhoeae</i> (NG) infection is a global and significant human public health issue. <b>Objectives</b>: Therefore, this meta-analysis aimed to estimate worldwide resistance rates of NG to the azithromycin and erythromycin according to years, regions, and antimicrobial susceptibility testing (AST). <b>Methods</b>: We systematically searched the published studies in PubMed, Scopus, and Embase from 1988 to 2021. All analyses were conducted using Stata software. <b>Results</b>: The 134 reports included in the meta-analysis were performed in 51 countries and examined 165,172 NG isolates. Most of the included studies were from Asia (50 studies) and Europe (46 studies). In the metadata, the global prevalence over the past 30 years were 6% for azithromycin and 48% for erythromycin. There was substantial change in the prevalence of macrolides NG resistance over time (<i>P</i> <0.01). In this metadata, among 58 countries reporting resistance data for azithromycin, 17 (29.3%) countries reported that >5% of specimens had azithromycin resistance. <b>Conclusions</b>: The implications of this study emphasize the rigorous or improved antimicrobial stewardship, early diagnosis, contact tracing, and enhanced intensive global surveillance system are crucial for control of further spreading of gonococcal emergence of antimicrobial resistance (AMR).</p>","PeriodicalId":48617,"journal":{"name":"Yale Journal of Biology and Medicine","volume":"95 4","pages":"465-478"},"PeriodicalIF":2.5000,"publicationDate":"2022-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/4e/a5/yjbm_95_4_465.PMC9765340.pdf","citationCount":"0","resultStr":"{\"title\":\"Global status of Azithromycin and Erythromycin Resistance Rates in <i>Neisseria gonorrhoeae</i>: A Systematic Review and Meta-analysis.\",\"authors\":\"Zhiwei Lu,&nbsp;Danyal Abbasi Tadi,&nbsp;Jinchao Fu,&nbsp;Khalil Azizian,&nbsp;Ebrahim Kouhsari\",\"doi\":\"\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><p><b>Background</b>: The widespread development of antibiotic resistance or decreased susceptibility in <i>Neisseria gonorrhoeae</i> (NG) infection is a global and significant human public health issue. <b>Objectives</b>: Therefore, this meta-analysis aimed to estimate worldwide resistance rates of NG to the azithromycin and erythromycin according to years, regions, and antimicrobial susceptibility testing (AST). <b>Methods</b>: We systematically searched the published studies in PubMed, Scopus, and Embase from 1988 to 2021. All analyses were conducted using Stata software. <b>Results</b>: The 134 reports included in the meta-analysis were performed in 51 countries and examined 165,172 NG isolates. Most of the included studies were from Asia (50 studies) and Europe (46 studies). In the metadata, the global prevalence over the past 30 years were 6% for azithromycin and 48% for erythromycin. There was substantial change in the prevalence of macrolides NG resistance over time (<i>P</i> <0.01). In this metadata, among 58 countries reporting resistance data for azithromycin, 17 (29.3%) countries reported that >5% of specimens had azithromycin resistance. <b>Conclusions</b>: The implications of this study emphasize the rigorous or improved antimicrobial stewardship, early diagnosis, contact tracing, and enhanced intensive global surveillance system are crucial for control of further spreading of gonococcal emergence of antimicrobial resistance (AMR).</p>\",\"PeriodicalId\":48617,\"journal\":{\"name\":\"Yale Journal of Biology and Medicine\",\"volume\":\"95 4\",\"pages\":\"465-478\"},\"PeriodicalIF\":2.5000,\"publicationDate\":\"2022-12-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/4e/a5/yjbm_95_4_465.PMC9765340.pdf\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Yale Journal of Biology and Medicine\",\"FirstCategoryId\":\"5\",\"ListUrlMain\":\"\",\"RegionNum\":3,\"RegionCategory\":\"工程技术\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q2\",\"JCRName\":\"BIOLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Yale Journal of Biology and Medicine","FirstCategoryId":"5","ListUrlMain":"","RegionNum":3,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"BIOLOGY","Score":null,"Total":0}
引用次数: 0

摘要

背景:淋病奈瑟菌(NG)感染中抗生素耐药性或敏感性降低的广泛发展是一个全球性和重大的人类公共卫生问题。因此,本荟萃分析旨在根据年份、地区和抗菌药敏试验(AST)估计全球NG对阿奇霉素和红霉素的耐药率。方法:系统检索1988 - 2021年在PubMed、Scopus和Embase上发表的研究。所有分析均使用Stata软件进行。结果:纳入meta分析的134份报告来自51个国家,检查了165,172株NG分离株。大多数纳入的研究来自亚洲(50项研究)和欧洲(46项研究)。在元数据中,过去30年阿奇霉素的全球流行率为6%,红霉素为48%。随着时间的推移,大环内酯类药物耐药的患病率发生了实质性变化(5%的标本对阿奇霉素耐药)。结论:本研究的意义强调严格或改进抗菌药物管理、早期诊断、接触者追踪和加强强化的全球监测系统对于控制淋球菌耐药性(AMR)的进一步传播至关重要。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

Global status of Azithromycin and Erythromycin Resistance Rates in <i>Neisseria gonorrhoeae</i>: A Systematic Review and Meta-analysis.

Global status of Azithromycin and Erythromycin Resistance Rates in <i>Neisseria gonorrhoeae</i>: A Systematic Review and Meta-analysis.

Global status of Azithromycin and Erythromycin Resistance Rates in <i>Neisseria gonorrhoeae</i>: A Systematic Review and Meta-analysis.

Global status of Azithromycin and Erythromycin Resistance Rates in Neisseria gonorrhoeae: A Systematic Review and Meta-analysis.

Background: The widespread development of antibiotic resistance or decreased susceptibility in Neisseria gonorrhoeae (NG) infection is a global and significant human public health issue. Objectives: Therefore, this meta-analysis aimed to estimate worldwide resistance rates of NG to the azithromycin and erythromycin according to years, regions, and antimicrobial susceptibility testing (AST). Methods: We systematically searched the published studies in PubMed, Scopus, and Embase from 1988 to 2021. All analyses were conducted using Stata software. Results: The 134 reports included in the meta-analysis were performed in 51 countries and examined 165,172 NG isolates. Most of the included studies were from Asia (50 studies) and Europe (46 studies). In the metadata, the global prevalence over the past 30 years were 6% for azithromycin and 48% for erythromycin. There was substantial change in the prevalence of macrolides NG resistance over time (P <0.01). In this metadata, among 58 countries reporting resistance data for azithromycin, 17 (29.3%) countries reported that >5% of specimens had azithromycin resistance. Conclusions: The implications of this study emphasize the rigorous or improved antimicrobial stewardship, early diagnosis, contact tracing, and enhanced intensive global surveillance system are crucial for control of further spreading of gonococcal emergence of antimicrobial resistance (AMR).

求助全文
通过发布文献求助,成功后即可免费获取论文全文。 去求助
来源期刊
Yale Journal of Biology and Medicine
Yale Journal of Biology and Medicine Biochemistry, Genetics and Molecular Biology-General Biochemistry,Genetics and Molecular Biology
CiteScore
5.00
自引率
0.00%
发文量
41
期刊介绍: The Yale Journal of Biology and Medicine (YJBM) is a graduate and medical student-run, peer-reviewed, open-access journal dedicated to the publication of original research articles, scientific reviews, articles on medical history, personal perspectives on medicine, policy analyses, case reports, and symposia related to biomedical matters. YJBM is published quarterly and aims to publish articles of interest to both physicians and scientists. YJBM is and has been an internationally distributed journal with a long history of landmark articles. Our contributors feature a notable list of philosophers, statesmen, scientists, and physicians, including Ernst Cassirer, Harvey Cushing, Rene Dubos, Edward Kennedy, Donald Seldin, and Jack Strominger. Our Editorial Board consists of students and faculty members from Yale School of Medicine and Yale University Graduate School of Arts & Sciences. All manuscripts submitted to YJBM are first evaluated on the basis of scientific quality, originality, appropriateness, contribution to the field, and style. Suitable manuscripts are then subject to rigorous, fair, and rapid peer review.
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
确定
请完成安全验证×
copy
已复制链接
快去分享给好友吧!
我知道了
右上角分享
点击右上角分享
0
联系我们:info@booksci.cn Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术官方微信