Thrombophilias

Thrombophilias are defined as conditions that increase one’s risk of developing thromboembolic phenomena. Most patients with these conditions are asymptomatic, except when in the presence of a secondary trigger, namely a high-risk situation (both physiologic and otherwise). Over the past years, the importance of recognizing these conditions, and the effects of early intervention, have been emphasized. In particular, in the field of obstetrics and gynecology, thrombophilias play a major role. As will be described, there are several well-defined conditions in pregnancy that have been found to be associated with these conditions. Appropriate early intervention may have a significant impact on pregnancy outcome. It is the responsibility of the physician to be familiar with these syndromes, their detection, and appropriate management. The theory behind these syndromes, a brief review of the coagulation cascade, a review of the individual syndromes, and special circumstances will be described below in an attempt to assist the primary care physician in becoming familiar with these conditions.