不孕妇女氧化应激生物标志物、一些血清白介素和激素水平的变化

S. M. Hamza, Sahib J Abd-alrahman
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引用次数: 0

摘要

本研究旨在探讨氧化应激对原发性不孕症妇女血清白细胞介素和激素水平的影响,并揭示两者之间的相关性。对120例不同病因的不孕妇女和45例有生育能力的妇女作为对照,年龄在16-45岁之间。测定血清TAC、SOD活性、GSH、MDA、Mg、Zn、过氧化氢酶活性、白细胞介素-1β和白细胞介素- 8水平,以及LH、FSH、催乳素、黄体酮、AMH、抑制素B和瘦素水平。结果显示,不育组和可育组血清MDA、白细胞介素- 1β、催乳素和瘦素水平显著升高,tac、SOD、GSH、Mg、Zn、过氧化氢酶活性、AMH和抑制素B水平显著降低。SOD与amh、抑制素B、Mg呈正相关,LH与FSH、TAC、抑制素B呈正相关,FSH与抑制素B呈负相关。综上所述,抑制素B可能在抗氧化平衡中起一定作用。
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Alterations in Levels of Oxidative Stress Biomarkers, Some Serum Interleukins and Hormones in Infertile Women
The aim of this study was to evaluate the effect of oxidative stress and someserum interleukins and hormones levels of women with primary infertility, and toreveal the correlation between them.A total of 120 infertile women with different etiologies and 45 fertile women as acontrol were investigated, their age ranged between (16-45) years old. The levels of serum TAC, SOD activity, GSH, MDA, Mg, Zn, catalase activity, interleukin-1β and interleukin- 8 were estimated, also the levels of LH, FSH, prolactin, progesterone, AMH, inhibin B and leptin were estimated.The current results were revealed that there was a significant elevation in thelevels of MDA, interleukin- 1β, prolactin and leptin, and a significant decrease inTAC, SOD, GSH, Mg, Zn, catalase activity, AMH and inhibin B between theinfertile and fertile groups. There was a positive correlation between SOD withAMH, inhibin B and Mg, and positive correlation between LH and FSH, TAC andinhibin B. there was a negative correlation between FSH and inhibinB. In conclusion, it suggested that inhibin B may play a role in theantioxidant–oxidant balance.
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